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Fabrication of Microfluidic Manifold by Precision Extrusion Deposition and Replica Molding for Cell-Laden Device
Journal article   Peer reviewed

Fabrication of Microfluidic Manifold by Precision Extrusion Deposition and Replica Molding for Cell-Laden Device

Jessica Snyder, Ae Rin Son, Qudus Hamid and Wei Sun
Journal of manufacturing science and engineering, v 138(4), pp 041007/1-041007/11
01 Apr 2016
DOI: https://doi.org/10.1115/1.4031551
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Engineering, Manufacturing Engineering, Mechanical Science & Technology Engineering Technology
A PED (precision extrusion deposition)/replica molding process enables scaffold guided tissue engineering of a heterocellular microfluidic device. We investigate two types of cell-laden devices: the first with a 3D microfluidic manifold fully embedded in a PDMS (polydimethylsiloxane) substrate and the second a channel network on the surface of the PDMS substrate for cell printing directly into device channels. Fully embedded networks are leak-resistant with simplified construction methods. Channels exposed to the surface are used as mold to hold bioprinted cell-laden matrix for controlled cell placement throughout the network from inlet to outlet. The result is a 3D cell-laden microfluidic device with improved leak-resistance (up to 2.0 mL/min), pervasive diffusion and control of internal architecture.

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7 Record Views
12 citations in Web of Science
19 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Engineering, Manufacturing
Engineering, Mechanical
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