Journal article
Fabrication of interconnected microporous biomaterials with high hydroxyapatite nanoparticle loading
Biofabrication, v 2(3), pp 035006-035006
Sep 2010
PMID: 20823506
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hydroxyapatite (HA) is known to promote osteogenicity and enhance the mechanical properties of biopolymers. However, incorporating a large amount of HA into a porous biopolymer still remains a challenge. In the present work, a new method was developed to produce interconnected microporous poly(glycolic-co-lactic acid) (PLGA) with high HA nanoparticle loading. First, a ternary blend comprising PLGA/PS (polystyrene)/HA (40/40/20 wt%) was prepared by melt blending under conditions for formation of a co-continuous phase structure. Next, a dynamic annealing stage under small-strain oscillation was applied to the blend to facilitate nanoparticle redistribution. Finally, the PS phase was sacrificially extracted, leaving a porous matrix. The results from different characterizations suggested that the applied small-strain oscillation substantially accelerated the migration of HA nanoparticles during annealing from the PS phase to the PLGA phase; nearly all HA particles were uniformly presented in the PLGA phase after a short period of annealing. After dissolution of the PS phase, a PLGA material with interconnected microporous structure was successfully produced, with a high HA loading above 30 wt%. The mechanisms beneath the experimental observations, particularly on the enhanced particle migration process, were discussed, and strategies for producing highly particle loaded biopolymers with interconnected microporous structures were proposed.
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Details
- Title
- Fabrication of interconnected microporous biomaterials with high hydroxyapatite nanoparticle loading
- Creators
- Wei Zhang - School of Polymer Textile and Fiber Engineering, Georgia Institute of Technology, Atlanta, GA, USADonggang YaoQingwei ZhangJack G ZhouPeter I Lelkes
- Publication Details
- Biofabrication, v 2(3), pp 035006-035006
- Publisher
- Institute of Physics (IOP); England
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000281674000007
- Scopus ID
- 2-s2.0-79952112513
- Other Identifier
- 991014877689904721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials