Journal article
Fabrication of three-dimensional scaffolds for heterogeneous tissue engineering
Biomedical microdevices, v 12(4), pp 721-725
01 Aug 2010
PMID: 20393801
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The development of biomedical scaffolds mimicking a heterogeneous cellular microenvironment for a specified regulation of cell-fates is very promising for tissue engineering. In this study, three-dimensional scaffolds with heterogeneous microstructure were developed using a DMD-PP apparatus. During the fabrication process, this apparatus can efficiently switch monomers to form microstructures with localized, different material properties; the resolution in the arrangement of material properties is comparable to the characteristic size of functional subunits in living organs, namely, a hundred microns. The effectiveness of this DMD-PP apparatus is demonstrated by a woodpile microstructure with heterogeneous fluorescence and also by a microporous cell-culturing scaffold with selected sites for protein adhesion. Cell-cultivation experiment was performed with the microporous scaffold, in which selective cell adhesion was observed.
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Details
- Title
- Fabrication of three-dimensional scaffolds for heterogeneous tissue engineering
- Creators
- Li-Hsin Han - Univ Texas Austin, Texas Mat Inst, Austin, TX 78712 USAShalu Suri - The University of Texas at AustinChristine E. Schmidt - The University of Texas at AustinShaochen Chen - The University of Texas at Austin
- Publication Details
- Biomedical microdevices, v 12(4), pp 721-725
- Publisher
- Springer Nature
- Number of pages
- 5
- Grant note
- National Science Foundation; National Science Foundation (NSF) Office of Naval Research
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics; Drexel University
- Web of Science ID
- WOS:000279500200016
- Scopus ID
- 2-s2.0-77957339860
- Other Identifier
- 991020100047304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Nanoscience & Nanotechnology