Journal article
Fabrication of three-dimensional scaffolds using precision extrusion deposition with an assisted cooling device
Biofabrication, v 3(3), pp 034109-1-11
01 Sep 2011
PMID: 21727312
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the field of biofabrication, tissue engineering and regenerative medicine, there are many methodologies to fabricate a building block (scaffold) which is unique to the target tissue or organ that facilitates cell growth, attachment, proliferation and/or differentiation. Currently, there are many techniques that fabricate three-dimensional scaffolds; however, there are advantages, limitations and specific tissue focuses of each fabrication technique. The focus of this initiative is to utilize an existing technique and expand the library of biomaterials which can be utilized to fabricate three-dimensional scaffolds rather than focusing on a new fabrication technique. An expanded library of biomaterials will enable the precision extrusion deposition (PED) device to construct three-dimensional scaffolds with enhanced biological, chemical and mechanical cues that will benefit tissue generation. Computer-aided motion and extrusion drive the PED to precisely fabricate micro-scaled scaffolds with biologically inspired, porosity, interconnectivity and internal and external architectures. The high printing resolution, precision and controllability of the PED allow for closer mimicry of tissues and organs. The PED expands its library of biopolymers by introducing an assisting cooling (AC) device which increases the working extrusion temperature from 120 to 250 degrees C. This paper investigates the PED with the integrated AC's capabilities to fabricate three-dimensional scaffolds that support cell growth, attachment and proliferation. Studies carried out in this paper utilized a biopolymer whose melting point is established to be 200 degrees C. This polymer was selected to illustrate the newly developed device's ability to fabricate three-dimensional scaffolds from a new library of biopolymers. Three-dimensional scaffolds fabricated with the integrated AC device should illustrate structural integrity and ability to support cell attachment and proliferation.
Metrics
Details
- Title
- Fabrication of three-dimensional scaffolds using precision extrusion deposition with an assisted cooling device
- Creators
- Q. Hamid - Drexel UniversityJ. Snyder - Drexel UniversityC. Wang - Drexel UniversityM. TimmerJ. HammerS. Guceri - Drexel UniversityW. Sun - Drexel University
- Publication Details
- Biofabrication, v 3(3), pp 034109-1-11
- Publisher
- Iop Publishing Ltd
- Number of pages
- 11
- Grant note
- Advanced Technologies and Regenerative Medicine (ATRM), LLC, a Johnson and Johnson Company; Johnson & Johnson; Johnson & Johnson USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Marketing; Chemical and Biological Engineering; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000294955200011
- Scopus ID
- 2-s2.0-82055184089
- Other Identifier
- 991019169305304721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials