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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Facial emotion recognition impairments are associated with brain volume abnormalities in individuals with HIV
Neuropsychologia, v 70, 263
01 Apr 2015
PMID: 25744868
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Impaired facial emotion recognition abilities in HIV+ patients are well documented, but little is known about the neural etiology of these difficulties. We examined the relation of facial emotion recognition abilities to regional brain volumes in 44 HIV-positive (HIV+) and 44 HIV-negative control (HC) adults. Volumes of structures implicated in HIV-associated neuropathology and emotion recognition were measured on MRI using an automated segmentation tool. Relative to HC, HIV+ patients demonstrated emotion recognition impairments for fearful expressions, reduced anterior cingulate cortex (ACC) volumes, and increased amygdala volumes. In the HIV+ group, fear recognition impairments correlated significantly with ACC, but not amygdala volumes. ACC reductions were also associated with lower nadir CD4 levels (i.e., greater HIV-disease severity). These findings extend our understanding of the neurobiological substrates underlying an essential social function, facial emotion recognition, in HIV+ individuals and implicate HIV-related ACC atrophy in the impairment of these abilities.
•Neural correlates of facial emotion recognition (FER) deficits in HIV are unknown•FER was tested in non-demented HIV+ and control adults•Brain regions implicated in HIV-related neuropathology and FER were measured on MRI•Fear recognition deficits were associated with ACC atrophy in the HIV group•Results support the neural etiology of emotion processing impairments in HIV
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Details
- Title
- Facial emotion recognition impairments are associated with brain volume abnormalities in individuals with HIV
- Creators
- Uraina S. Clark - Brown UniversityKeenan A. Walker - St. John's UniversityRonald A. Cohen - Brown UniversityKathryn N. Devlin - Miriam HospitalAnna M. Folkers - Miriam HospitalMatthew J. Pina - Miriam HospitalKaren T. Tashima - Miriam Hospital
- Publication Details
- Neuropsychologia, v 70, 263
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000354596900027
- Scopus ID
- 2-s2.0-84924597441
- Other Identifier
- 991021448168604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Psychology, Experimental