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Factors Contributing to Global Cognitive Impairment in Heart Failure: Results From a Population-Based Cohort
Journal article   Open access   Peer reviewed

Factors Contributing to Global Cognitive Impairment in Heart Failure: Results From a Population-Based Cohort

Patrick M. Pullicino, Virginia G. Wadley, Leslie A. McClure, Monika M. Safford, Ronald M. Lazar, Marc Klapholz, Ali Ahmed, Virginia J. Howard and George Howard
Journal of cardiac failure, v 14(4), pp 290-295
2008
DOI: https://doi.org/10.1016/j.cardfail.2008.01.003
PMID: 18474341
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc2730643View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Anemia depression neuropsychology stroke
Heart failure (HF) and cognitive impairment are both common in older adults. However, the association between the two has not been well studied. We explored the relationship between very probable HF, determined by self-reported symptoms, and cognitive impairment, defined as four or fewer correct on the Six-item Screener, in 14,089 participants of the Reasons for Geographic and Racial Differences in Stroke cohort. We determined the effect of adding demographic, socioeconomic status (SES), health behavior, and comorbidity covariates. In the univariate model, participants with very probable HF were 1.51 (95% confidence interval: 1.15–1.96) times more likely to have cognitive impairment than those without HF. As covariates were added to the model, the relationship between HF and cognitive impairment was attenuated and lost statistical significance after adjustment for depression. Demographic variables, Stroke Belt location (1.28 [1.11–1.48]), SES factors, prior stroke (1.43 [1.18–1.73]), and depression (1.66 [1.38–2.01]) remained significant in the multivariable model. Higher hemoglobin was associated (0.95 [0.9–1.00]) with modestly reduced odds of cognitive impairment. The relationship between cognitive impairment and HF can be accounted for by multiple demographic and SES factors, and by comorbidities, some of which are modifiable. Persons with HF and cognitive impairment should be screened for anemia and depression.

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47 citations in Web of Science
50 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
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