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Factors associated with development of early and late pulmonary hypertension in preterm infants with bronchopulmonary dysplasia
Journal article   Open access   Peer reviewed

Factors associated with development of early and late pulmonary hypertension in preterm infants with bronchopulmonary dysplasia

Sudip Sheth, Lisa Goto, Vineet Bhandari, Boban Abraham and Anja Mowes
Journal of perinatology, v 40(1), pp 138-148
Jan 2020
DOI: https://doi.org/10.1038/s41372-019-0549-9
PMID: 31723236
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1038/s41372-019-0549-9View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Bronchopulmonary Dysplasia - complications Case-Control Studies Cerebral Intraventricular Hemorrhage - complications Female Humans Hypertension, Pulmonary - etiology Infant, Newborn Infant, Premature Infant, Premature, Diseases - etiology Logistic Models Pregnancy Pregnancy in Diabetics Retrospective Studies Risk Factors
To investigate factors associated with development of early and late pulmonary hypertension (E/LPH) in preterm infants with bronchopulmonary dysplasia (BPD). A retrospective case-control observational study of preterm infants with BPD admitted to a level IV referral neonatal intensive care unit over 5 years. We compared pre- and postnatal characteristics between infants with or without BPD-associated EPH and LPH. Fifty-nine out of 220 infants (26.8%) had LPH, while 85 out of 193 neonates (44%) had EPH. On multiple logistic regression, novel factors associated with development of BPD-LPH included presence of maternal diabetes, EPH, tracheostomy, tracheitis, intraventricular hemorrhage (IVH, grade ≥3) and systemic steroid use. For EPH, these were maternal diabetes, IVH grade ≥3, high frequency ventilator use, and absence of maternal antibiotics use. We identified novel factors and confirmed previously established factors with development of LPH and EPH, which can help develop a screening strategy in BPD patients.

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41 citations in Web of Science
42 citations in Scopus

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Web of Science research areas
Obstetrics & Gynecology
Pediatrics
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