Journal article
Factors associated with high myopia after 7 years of follow-up in the Correction of Myopia Evaluation Trial (COMET) Cohort
Ophthalmic epidemiology, v 14(4), pp 230-237
01 Jan 2007
PMID: 17896302
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate factors associated with the development of high myopia (worse than -6.00 D) over 7 years of follow-up in the COMET cohort.
COMET enrolled 469 ethnically diverse children (6-11 years) with myopia between -1.25 and -4.50 D. They were randomized to either progressive addition lenses (PALs) or single vision lenses (SVLs), and followed for 5 years in their original lens assignment and 2 additional years wearing either spectacles (PALs or SVLs) or contact lenses. Refractive error was measured annually by cycloplegic autorefraction and axial length by A-Scan ultrasonography. Myopia for each child was defined as the mean spherical equivalent refractive error (SER) of the 2 eyes. Analyses were based on 7 years of follow-up. Time to high myopia was analyzed by Cox proportional hazard models and linear regression. Parental refraction data were available from 240 COMET subjects.
Younger (6-7 years) versus older (11 years) age at baseline was a significant risk factor (adjusted hazard ratio (HR) = 6.6, 95% CI = 3.4, 12.7) for having high myopia within 7 years. More (SER from -2.26 to -4.50 D) vs. less (SER from -1.25 to -2.25 D) baseline myopia was also a significant risk factor for high myopia at 7 years (adjusted HR = 7.4, 95% CI = 4.4, 12.4). Gender, ethnicity, and treatment assignment were not associated with the risk of high myopia within 7 years. Increased number of myopic parents was associated with a significant risk of high myopia in the children (p = 0.008).
Children who developed high myopia during 7 years of follow-up were younger and had more myopia at baseline. They also were more likely to have two myopic parents. These children may be at greater risk for sight-threatening conditions later in life.
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Details
- Title
- Factors associated with high myopia after 7 years of follow-up in the Correction of Myopia Evaluation Trial (COMET) Cohort
- Creators
- Jane Gwiazda - New England College of OptometryLeslie Hyman - Stony Brook SchoolLi Ming Dong - Stony Brook SchoolDon Everett - National Institutes of HealthTom NortonDan Kurtz - New England College of OptometryRuth MannyWendy Marsh-TootleMitch ScheimanComet Group
- Publication Details
- Ophthalmic epidemiology, v 14(4), pp 230-237
- Publisher
- Taylor and Francis
- Grant note
- EY11756 / NEI NIH HHS EY11754 / NEI NIH HHS EY11740 / NEI NIH HHS EY11755 / NEI NIH HHS EY11752 / NEI NIH HHS EY11805 / NEI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000249724700014
- Scopus ID
- 2-s2.0-34848919498
- Other Identifier
- 991021900615004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology