Journal article
Factors that predict the burden of axillary disease in breast cancer patients with a positive sentinel node
American journal of clinical oncology, v 31(1), pp 34-38
01 Feb 2008
PMID: 18376225
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: This study identifies clinical and pathologic factors predictive of having >= 4 involved axillary lymph nodes in breast cancer patients with a positive sentinel node. These factors may influence radiation therapy decisions.
Methods: We reviewed the records of 201 patients with positive SLN who underwent axillary dissection; 34 of these patients had >= 4 positive axillary lymph nodes. Factors associated with >= 4 lymph nodes were evaluated by chi(2) test, and multivariate logistic regression model was used to identify independent factors.
Results: On univariate analysis, presence of lymphovascular space invasion, extracapsular extension, increased number of positive SLN, increased size of tumor, macrometastases within the SLN, and decreased number of negative SLN were all significantly associated with having >= 4 involved axillary lymph nodes. On multivariate analysis, presence of extracapsular extension (odds ratio [OR] = 3.76, P = 0.004), increased number of positive SLN (OR = 3.99, P = 0.006), increased size of tumor (OR = 3.33, P = 0.011 for size of 2.1 to 5 cm and OR = 8.28, P = 0.018 for size >5 cm), and decreased number of negative SLN (OR = 2.62, P = 0.037) were found to be significant.
Conclusion: We have identified primary tumor and SLN variables that predict for a greater probability of having a significant burden of residual disease in the axilla that may affect treatment recommendations.
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Details
- Title
- Factors that predict the burden of axillary disease in breast cancer patients with a positive sentinel node
- Creators
- Sushil Beriwal - UPMC Hillman Cancer CenterAtilla Soran - UPMC Hillman Cancer CenterBelma Kocer - University of PittsburghJohn W. Wilson - UPMC Hillman Cancer CenterGretchen M. Ahrendt - UPMC Hillman Cancer CenterRonald Johnson - UPMC Hillman Cancer Center
- Publication Details
- American journal of clinical oncology, v 31(1), pp 34-38
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000253102700006
- Scopus ID
- 2-s2.0-42449092490
- Other Identifier
- 991021897286804721
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InCites Highlights
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- Web of Science research areas
- Oncology