Journal article
False versus True Statin Intolerance in Patients with Peripheral Artery Disease
JOURNAL OF CLINICAL MEDICINE, v 11(22), 6619
Nov 2022
PMID: 36431097
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Statin intolerance (SI) is often documented in patients' charts but rarely confirmed by objective methods. Objective: We aimed to identify the rate of true SI in a large population with peripheral artery disease (PAD) as well as the subsequent use of such drugs and the impact on cardiovascular outcomes. Methods: Patients with PAD and reported SI were retrospectively classified in those with probable/possible (pp) and unlikely (u) SI, after the application of the Statin Myalgia Clinical Index Score (SAMS-CI). Both groups were compared after 62 months (date of observation period?). Results: Among the 4,505 included patients, 139 (3%) had been reported as having SI. Of those, 33 (24%) had ppSI, and 106 (76%) had uSI. During the observation period, statin use decreased in patients with both ppSI (from 97% to 21%; p < 0.0001) and uSI (from 87% to 53%; p < 0.0001). At the end of the observation period, patients with ppSI more often received PCSK9 inhibitors (55% vs. 7%; p < 0.0001), had a stronger decrease in LDL-C from baseline to follow-up (1.82 +/- 1.69 mmol/L vs. 0.85 +/- 1.41 mmol/L; p < 0.01), and a lower rate of mortality (3% vs. 21%; p = 0.04) than those with uSI. Conclusions: SI is low in PAD patients (3.1%), with only one quarter fulfilling the criteria of ppSI. The overdiagnosis of SI is related to an underuse of statins and an increased mortality in a short time period.
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Details
- Title
- False versus True Statin Intolerance in Patients with Peripheral Artery Disease
- Publication Details
- JOURNAL OF CLINICAL MEDICINE, v 11(22), 6619
- Publisher
- MDPI; BASEL
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000887480600001
- Scopus ID
- 2-s2.0-85142357945
- Other Identifier
- 991021860716204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems