Journal article
Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development
Autism research, v 12(1)
Jan 2019
PMCID: PMC6467644
PMID: 30095240
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Numerous studies have reported immune system disturbances in individuals with autism and their family members; however, there is considerable variability in findings with respect to the specific immune conditions involved, their timing, and the family members affected and little understanding of variation by autism subphenotype. Using data from the Study to Explore Early Development (SEED), a multi-site case-control study of children born 2003-2006 in the United States, we examined the role of family history of autoimmune diseases, asthma, and allergies in autism spectrum disorder (ASD) as well as other developmental disorders (DD). We investigated maternal immune conditions during the pregnancy period, as well as lifetime history of these conditions in several family members (mother, father, siblings, and study child). Logistic regression analyses included 663 children with ASD, 984 children with DD, and 915 controls ascertained from the general population (POP). Maternal history of eczema/psoriasis and asthma was associated with a 20%-40% increased odds of both ASD and DD. Risk estimates varied by specific ASD subphenotypes in association with these exposures. In addition, children with ASD were more likely to have a history of psoriasis/eczema or allergies than POP controls. No association was observed for paternal history or family history of these immune conditions for either ASD or DD. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes, and further suggest that associations may differ by ASD phenotype of the child. Autism Research 2019, 12: 123-135. © 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multi-site study in the US-the Study to Explore Early Development-we found that women with a history of eczema/psoriasis and asthma are more likely to have children with ASD or DD. In addition, children with ASD are more likely to have a history of psoriasis/eczema or allergies than typically developing children. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes.
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Details
- Title
- Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development
- Creators
- Lisa A Croen - Kaiser Permanente Oakland Medical CenterYinge Qian - Kaiser Permanente Oakland Medical CenterPaul Ashwood - University of California Davis Medical CenterJulie L Daniels - University of North Carolina at Chapel HillDaniele Fallin - Johns Hopkins UniversityDiana Schendel - Lundbeck FoundationLaura A Schieve - National Center on Birth Defects and Developmental DisabilitiesAlison B Singer - University of North Carolina at Chapel HillOusseny Zerbo - Kaiser Permanente Oakland Medical Center
- Publication Details
- Autism research, v 12(1)
- Publisher
- Wiley
- Grant note
- Colorado Department of Public Health and Environment U01 DD000498 / NCBDD CDC HHS U10 DD000181 / NCBDD CDC HHS U10 DD000180 / NCBDD CDC HHS Michigan State University R21 ES025560 / NIEHS NIH HHS U54 HD079125 / NICHD NIH HHS U10 DD000183 / NCBDD CDC HHS R21 MH116383 / NIMH NIH HHS U54 HD079124 / NICHD NIH HHS U10 DD000182 / NCBDD CDC HHS U10 DD000184 / NCBDD CDC HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000455050300012
- Scopus ID
- 2-s2.0-85052641109
- Other Identifier
- 991021463448604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Behavioral Sciences
- Psychology, Developmental