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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Fast oscillations during gasping and other non-eupneic respiratory behaviors: Clues to central pattern generation
Respiratory physiology & neurobiology, v 187(2)
15 Jun 2013
PMCID: PMC3696890
PMID: 23545119
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The mammalian nervous system exhibits fast synchronous oscillations, which are especially prominent in respiratory-related nerve discharges. In the phrenic nerve, they include high-(HFO), medium-(MFO), and low-frequency (LFO) oscillations. Because motoneurons firing at HFO-related frequencies had never been recorded, an epiphenomenological mechanism for their existence had been posited. We have recently recorded phrenic motoneurons firing at HFO-related frequencies in unanesthetized decerebrate rats and showed that they exhibit dynamic coherence with the phrenic nerve, validating synchronous motoneuronal discharge as a mechanism underlying the generation of HFO. In so doing, we have helped validate the conclusions of previous studies by us and other investigators who have used changes in fast respiratory oscillations to make inferences about central respiratory pattern generation. Here, we seek to review changes occurring in fast synchronous oscillations during non-eupneic respiratory behaviors, with special emphasis on gasping, and the inferences that can be drawn from these dynamics regarding respiratory pattern formation. (C) 2013 Elsevier B.V. All rights reserved.
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Details
- Title
- Fast oscillations during gasping and other non-eupneic respiratory behaviors: Clues to central pattern generation
- Creators
- Michael George Zaki Ghali - Drexel UniversityVitaliy Marchenko - Drexel University
- Publication Details
- Respiratory physiology & neurobiology, v 187(2)
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- R01 NS069220 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01NS069220 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000320744300006
- Scopus ID
- 2-s2.0-84878370531
- Other Identifier
- 991019312457604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Physiology
- Respiratory System