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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering
Molecular bioSystems, v 11(1), pp 38-59
01 Jan 2015
PMCID: PMC4276719
PMID: 25360565
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Fatty acids are primary metabolites synthesized by complex, elegant, and essential biosynthetic machinery. Fatty acid synthases resemble an iterative assembly line, with an acyl carrier protein conveying the growing fatty acid to necessary enzymatic domains for modification. Each catalytic domain is a unique enzyme spanning a wide range of folds and structures. Although they harbor the same enzymatic activities, two different types of fatty acid synthase architectures are observed in nature. During recent years, strained petroleum supplies have driven interest in engineering organisms to either produce more fatty acids or specific high value products. Such efforts require a fundamental understanding of the enzymatic activities and regulation of fatty acid synthases. Despite more than one hundred years of research, we continue to learn new lessons about fatty acid synthases' many intricate structural and regulatory elements. In this review, we summarize each enzymatic domain and discuss efforts to engineer fatty acid synthases, providing some clues to important challenges and opportunities in the field.
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Details
- Title
- Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering
- Creators
- Joris Beld - University of California, San DiegoD. John Lee - Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USAMichael D. Burkart - University of California, San DiegoUniv. of California, San Diego, CA (United States)
- Publication Details
- Molecular bioSystems, v 11(1), pp 38-59
- Publisher
- Royal Soc Chemistry
- Number of pages
- 22
- Grant note
- R01GM095970 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01GM095970 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) 500-10-039 / California Energy Commission CILMSF DE-EE0003373 / DOE; United States Department of Energy (DOE)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000345897600004
- Scopus ID
- 2-s2.0-84919361067
- Other Identifier
- 991020535064904721
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- Web of Science research areas
- Biochemistry & Molecular Biology