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Journal article
Feasibility study on dosimetry verification of volumetric‐modulated arc therapy‐based total marrow irradiation
Journal of applied clinical medical physics, v 14(2), pp 15-23
Mar 2013
PMID: 23470926
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study was to develop dosimetry verification procedures for volumetric‐modulated arc therapy (VMAT)‐based total marrow irradiation (TMI). The VMAT based TMI plans were generated for three patients: one child and two adults. The planning target volume (PTV) was defined as bony skeleton, from head to mid‐femur, with a 3 mm margin. The plan strategy similar to published studies was adopted. The PTV was divided into head and neck, chest, and pelvic regions, with separate plans each of which is composed of 2–3 arcs/fields. Multiple isocenters were evenly distributed along the patient's axial direction. The focus of this study is to establish a dosimetry quality assurance procedure involving both two‐dimensional (2D) and three‐dimensional (3D) volumetric verifications, which is desirable for a large PTV treated with multiple isocenters. The 2D dose verification was performed with film for gamma evaluation and absolute point dose was measured with ion chamber, with attention to the junction between neighboring plans regarding hot/cold spots. The 3D volumetric dose verification used commercial dose reconstruction software to reconstruct dose from electronic portal imaging devices (EPID) images. The gamma evaluation criteria in both 2D and 3D verification were 5% absolute point dose difference and 3 mm of distance to agreement. With film dosimetry, the overall average gamma passing rate was 98.2% and absolute dose difference was 3.9% in junction areas among the test patients; with volumetric portal dosimetry, the corresponding numbers were 90.7% and 2.4%. A dosimetry verification procedure involving both 2D and 3D was developed for VMAT‐based TMI. The initial results are encouraging and warrant further investigation in clinical trials.
PACS number: 87.55.Qr
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Details
- Title
- Feasibility study on dosimetry verification of volumetric‐modulated arc therapy‐based total marrow irradiation
- Creators
- Yun Liang - University of California San DiegoGwe‐Ya Kim - University of California San DiegoTodd Pawlicki - University of California San DiegoArno J. Mundt - University of California San DiegoLoren K. Mell - University of California San Diego
- Publication Details
- Journal of applied clinical medical physics, v 14(2), pp 15-23
- Publisher
- John Wiley and Sons Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000315898300003
- Scopus ID
- 2-s2.0-84874974115
- Other Identifier
- 991021897328704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging