Journal article
Feature Integration Drives Probabilistic Behavior in the Drosophila Escape Response
Neuron (Cambridge, Mass.), v 94(6), pp 1190-1204.e6
21 Jun 2017
PMID: 28641115
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Animals rely on dedicated sensory circuits to extract and encode environmental features. How individual neurons integrate and translate these features into behavioral responses remains a major question. Here, we identify a visual projection neuron type that conveys predator approach information to the Drosophila giant fiber (GF) escape circuit. Genetic removal of this input during looming stimuli reveals that it encodes angular expansion velocity, whereas other input cell type(s) encode angular size. Motor program selection and timing emerge from linear integration of these two features within the GF. Linear integration improves size detection invariance over prior models and appropriately biases motor selection to rapid, GF-mediated escapes during fast looms. Our findings suggest feature integration, and motor control may occur as simultaneous operations within the same neuron and establish the Drosophila escape circuit as a model system in which these computations may be further dissected at the circuit level.
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Details
- Title
- Feature Integration Drives Probabilistic Behavior in the Drosophila Escape Response
- Creators
- Catherine R. von Reyn - Drexel UniversityAljoscha Nern - Howard Hughes Medical InstituteW. Ryan Williamson - Howard Hughes Medical InstitutePatrick Breads - Howard Hughes Medical InstituteMing Wu - Howard Hughes Medical InstituteShigehiro Namiki - Howard Hughes Medical InstituteGwyneth M. Card (Corresponding Author) - Howard Hughes Medical Institute
- Publication Details
- Neuron (Cambridge, Mass.), v 94(6), pp 1190-1204.e6
- Publisher
- Elsevier
- Number of pages
- 21
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000403820200016
- Scopus ID
- 2-s2.0-85027274144
- Other Identifier
- 991019169803704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences