Journal article
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Nature communications, v 15(1), pp 216-216
03 Jan 2024
PMID: 38172101
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.
Metrics
Details
- Title
- Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
- Creators
- Al Ozonoff - Boston UniversityNaresh Doni Jayavelu - Seattle UniversityShanshan Liu - Boston UniversityEsther Melamed - The University of Texas at AustinCarly E Milliren - Boston Children's HospitalJingjing Qi - Icahn School of Medicine at Mount SinaiLinda N Geng - Stanford UniversityGrace A McComsey - University Hospitals of ClevelandCharles B Cairns - Drexel UniversityLindsey R Baden - Brigham and Women's HospitalJoanna Schaenman - University of California, Los AngelesAlbert C Shaw - Yale UniversityHady Samaha - Emory UniversityVicki Seyfert-Margolis - MyOwnMed, Inc, Bethesda, MD, USAFlorian Krammer - Icahn School of Medicine at Mount SinaiLindsey B Rosen - National Institute of Allergy and Infectious DiseasesHanno Steen - Boston Children's HospitalCaitlin Syphurs - Boston UniversityRavi Dandekar - University of California, San FranciscoCasey P Shannon - Prevention of Organ FailureRafick P Sekaly - Case Western Reserve UniversityLauren I R Ehrlich - The University of Texas at AustinDavid B Corry - Michael E. DeBakey VA Medical CenterFarrah Kheradmand - Michael E. DeBakey VA Medical CenterMark A Atkinson - University of South FloridaScott C Brakenridge - University of South FloridaNelson I Agudelo Higuita - University of Oklahoma Health Sciences CenterJordan P Metcalf - University of Oklahoma Health Sciences CenterCatherine L Hough - Oregon Health & Science UniversityWilliam B Messer - Oregon Health & Science UniversityBali Pulendran - Stanford UniversityKari C Nadeau - Stanford UniversityMark M Davis - Stanford UniversityAna Fernandez Sesma - Icahn School of Medicine at Mount SinaiViviana Simon - Icahn School of Medicine at Mount SinaiHarm van Bakel - Icahn School of Medicine at Mount SinaiSeunghee Kim-Schulze - Icahn School of Medicine at Mount SinaiDavid A Hafler - Yale UniversityOfer Levy - Brigham and Women's HospitalMonica Kraft - University of ArizonaChris Bime - University of ArizonaElias K Haddad - Drexel UniversityCarolyn S Calfee - University of California, San FranciscoDavid J Erle - University of California, San FranciscoCharles R Langelier - University of California, San FranciscoWalter Eckalbar - University of California, San FranciscoSteven E Bosinger - Emory UniversityBjoern Peters - La Jolla Institute for ImmunologySteven H Kleinstein - Yale UniversityElaine F Reed - University of California, Los AngelesAlison D Augustine - National Institute of Allergy and Infectious DiseasesJoann Diray-Arce - Boston Children's HospitalHolden T Maecker - Stanford UniversityMatthew C Altman - Seattle UniversityRuth R Montgomery - Yale UniversityPatrice M Becker - National Institute of Allergy and Infectious DiseasesNadine Rouphael - Emory UniversityIMPACC Network
- Publication Details
- Nature communications, v 15(1), pp 216-216
- Publisher
- Springer Nature
- Grant note
- U19 AI089992 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:001136417200012
- Scopus ID
- 2-s2.0-85181510888
- Other Identifier
- 991021815015404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
Highly Cited Paper
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental