Journal article
Ferric ion crosslinking-based 3D printing of a graphene oxide hydrogel and its evaluation as a bio-scaffold in tissue engineering
Biotechnology and bioengineering, v 118(2), pp 1006-1012
01 Feb 2021
PMID: 33022744
Abstract
As a precursor of graphene, graphene oxide (GO) exhibits excellent mechanical, thermal, and electrical properties, besides appreciable biocompatibility in tissue engineering applications. However, the current GO-3D fabrication technology is still in need of optimization and simplification to ensure fine architecture and reasonable mechanical properties, which would further promote the performance of GO as bio-scaffolds in cell or microorganism attachment and in material transformation. To address this issue, we proposed a GO ink, with appreciable rheological properties and excellent printing performance via high-speed centrifugation and ferric ion-assisted cross-linking. A woodpile structure with controllable micro-pores was produced by micro-extrusion-based 3D printing technology followed by an optimized freeze-drying process. Cellular adhesion and viability were verified by inoculation and culture of HepaRG cells using the fabricated GO 3D structure, thus suggesting ferric ion-assisted cross-linking and controllable pore distribution for improving the performance of the GO construct as a bio-scaffold for in vitro liver tissue models.
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Details
- Title
- Ferric ion crosslinking-based 3D printing of a graphene oxide hydrogel and its evaluation as a bio-scaffold in tissue engineering
- Creators
- Renhao Lu - Tsinghua Univ, Dept Mech Engn, Biomfg Ctr, Beijing, Peoples R ChinaWuhua Zhang - Tsinghua UniversityYuting He - Key Laboratory of Low-grade Energy Utilization Technologies and Systems Chongqing University, Ministry of Education Chongqing ChinaSiyuan Zhang - Tsinghua UniversityQian Fu - Chongqing Univ, Inst Engn Thermophys, Sch Energy & Power Engn, Chongqing, Peoples R ChinaYuan Pang - Tsinghua UniversityWei Sun - Tsinghua University
- Publication Details
- Biotechnology and bioengineering, v 118(2), pp 1006-1012
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- 51805294 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2018YFA0703004 / National Key Research and Development Program of China 20197050024 / Tsinghua University Initiative Scientific Research Program G2017002 / 111 Project; Ministry of Education, China - 111 Project 20191080843 / Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000579476300001
- Scopus ID
- 2-s2.0-85092930353
- Other Identifier
- 991019167594904721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology