Journal article
Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
American journal of perinatology, v 37(7), pp 745-753
23 May 2019
PMID: 31121635
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
Objective
To determine the relationship between fetal exposure to intra-amniotic infection/inflammation (IAI) and fetal heart ventricular function as assessed by circulatory levels of N-terminal fragment brain natriuretic protein (NT-proBNP) and the Tei index.
Study Design
We analyzed 70 samples of paired amniotic fluid (AF) and cord blood retrieved from mothers who delivered preterm at <34 weeks as follows: Yes-IAI (
n
= 36) and No-IAI (
n
= 34). IAI was diagnosed by amniocentesis and AF mass spectrometry. Fetal exposure to inflammation was determined through the evaluation of cord blood haptoglobin (Hp) switch-on status and level, and interleukin (IL)-6 levels by Western blotting and enzyme-linked immunosorbent assay, respectively. Fetal heart function was assessed by cord blood NT-proBNP immunoassay and fetal echocardiogram (Tei index).
Results
IAI was characterized by significantly higher levels of AF (
p
< .001) and umbilical cord IL-6 (
p
= 0.004). Cord blood Hp levels and frequency of switch-on status were higher in fetuses exposed to IAI (
p
< 0.001, both). Fetuses exposed to IAI did not have higher levels of NT-proBNP. Following correction for gestational age and race, neither cord blood NT-proBNP nor the Tei index was significantly different in fetuses with Hp switched-on status (
p
> 0.05, both).
Conclusion
Fetal myocardial left ventricular function does not seem to be significantly impaired in fetuses born alive due to IAI if delivery of the fetus occurs immediately following the diagnosis of IAI.
Metrics
Details
- Title
- Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
- Creators
- Roxanna A. Irani - Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine, University of California San Francisco, San Francisco, CaliforniaCatalin S. Buhimschi - University of Illinois at ChicagoSarah N. Cross - University of MinnesotaGuomao Zhao - University of Illinois at ChicagoJoshua A. Copel - Yale UniversityVineet Bhandari - Drexel UniversityIrina A. Buhimschi - University of Illinois at ChicagoMert Ozan Bahtiyar - Yale University
- Publication Details
- American journal of perinatology, v 37(7), pp 745-753
- Publisher
- Thieme Medical Publishers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000536679800012
- Scopus ID
- 2-s2.0-85085233762
- Other Identifier
- 991019167457104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics