Journal article
Fetal Transplants Alter the Development of Function after Spinal Cord Transection in Newborn Rats
The Journal of neuroscience, v 17(12), pp 4856-4872
15 Jun 1997
PMID: 9169544
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pieces of fetal spinal tissue were transplanted into the site of complete midthoracic spinal transections in neonatal rat pups (transplant rats). The development of locomotion in these animals was compared with that of unoperated control rats and rats that received spinal transections alone (spinal rats). Reflex, treadmill and overground locomotion, staircase descent, and horizontal ladder crossing for a water reward were tested in control, spinal, and transplant rats from 3 weeks to adulthood. All tests were readily performed by control animals. Most spinal rats were unable to make many linked weight-supported steps on these tasks. Transplant rats were variable in their locomotor capabilities, but a subset of rats were able to demonstrate coordinated and adaptable locomotion on these tasks. Some transplant rats performed better on more challenging tasks, suggesting that motor strategies for these tasks used different information, perhaps from descending systems. Transplanted tissue survived, and in most cases there was immunocytochemical staining of serotonergic fibers passing into and caudal to the transplant, supporting the conclusion that descending systems grew through the transplanted tissue. Integration with the host tissue was often poor, suggesting that nonspecific or trophic effects of the transplant might also contribute to the development of locomotor function. Therefore several mechanisms may contribute to the repair of injured spinal cord provided by transplants that permit the development of useful locomotion.
Metrics
Details
- Title
- Fetal Transplants Alter the Development of Function after Spinal Cord Transection in Newborn Rats
- Creators
- Dorene MiyaSimon GiszterFutoshi MoriVijayalakshmi AdipudiAlan TesslerMarion Murray
- Publication Details
- The Journal of neuroscience, v 17(12), pp 4856-4872
- Publisher
- Society for Neuroscience
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997XG31800034
- Scopus ID
- 2-s2.0-0030919912
- Other Identifier
- 991014878047504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences