Journal article
Fetal Transplants Rescue Axial Muscle Representations in M1 Cortex of Neonatally Transected Rats That Develop Weight Support
Journal of neurophysiology, v 80(6), pp 3021-3030
01 Dec 1998
PMID: 9862903
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Abstract
Giszter, Simon, William Kargo, Michelle Davies, and Motohide Shibayama. Fetal transplants rescue axial muscle representations in M1 cortex of neonatally transected rats that develop weight support. J. Neurophysiol. 80: 3021–3030, 1998. Intraspinal transplants of fetal spinal tissue partly alleviate motor deficits caused by spinal cord injury. How transplants modify body representation and muscle recruitment by motor cortex is currently largely unknown. We compared electromyographic responses from motor cortex stimulation in normal adult rats, adult rats that received complete spinal cord transection at the T
8
–T
10
segmental level as neonates (TX rats), and similarly transected rats receiving transplants of embryonic spinal cord (TP rats). Rats were also compared among treatments for level of weight support and motor performance. Sixty percent of TP rats showed unassisted weight-supported locomotion as adults, whereas ∼30% of TX rats with no intervention showed unassisted weight-supported locomotion. In the weight-supporting animals we found that the transplants enabled motor responses to be evoked by microstimulation of areas of motor cortex that normally represent the lumbar axial muscles in rats. These same regions were silent in all TX rats with transections but no transplants, even those exhibiting locomotion with weight support. In weight-supporting TX rats low axial muscles could be recruited from the rostral cortical axial representation, which normally represents the neck and upper trunk. No operated animal, even those with well-integrated transplants and good weight-supported locomotion, had a hindlimb motor representation in cortex. The data demonstrate that spinal transplants allow the development of some functional interactions between areas of motor cortex and spinal cord that are not available to the rat lacking the intervention. The data also suggest that operated rats that achieve weight support may primarily use the axial muscles to steer the pelvis and hindlimbs indirectly rather than use explicit hindlimb control during weight-supported locomotion.
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Details
- Title
- Fetal Transplants Rescue Axial Muscle Representations in M1 Cortex of Neonatally Transected Rats That Develop Weight Support
- Creators
- Simon F. Giszter - Allegheny University of the Health SciencesWilliam J. Kargo - Allegheny University of the Health SciencesMichelle Davies - Allegheny University of the Health SciencesMotohide Shibayama - Allegheny University of the Health Sciences
- Publication Details
- Journal of neurophysiology, v 80(6), pp 3021-3030
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000077835000019
- Scopus ID
- 2-s2.0-0032432820
- Other Identifier
- 991019167682204721
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- Web of Science research areas
- Neurosciences
- Physiology