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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Fetal inflammatory response and brain injury in the preterm newborn
Journal of child neurology, v 24(9), pp 1119-1126
01 Sep 2009
PMID: 19605775
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Preterm birth can be caused by intrauterine infection and maternal/fetal inflammatory responses. Maternal inflammation (chorioamnionitis) is often followed by a systemic fetal inflammatory response characterized by elevated levels of proinflammatory cytokines in the fetal circulation. The inflammation signal is likely transmitted across the blood-brain barrier and initiates a neuroinflammatory response. Microglial activation has a central role in this process and triggers excitotoxic, inflammatory, and oxidative damage in the developing brain. Neuroinflammation can persist over a period of time and sensitize the brain to subinjurious insults in early and chronic phases but may offer relative tolerance in the intermediate period through activation of endogenous anti-inflammatory, protective, and repair mechanisms. Neuroinflammatory injury not only destroys what exists but also changes what develops.
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Details
- Title
- Fetal inflammatory response and brain injury in the preterm newborn
- Creators
- Shadi Malaeb - Tufts Children's HospitalOlaf Dammann - Tufts Children's Hospital
- Publication Details
- Journal of child neurology, v 24(9), pp 1119-1126
- Publisher
- Sage
- Grant note
- 5R13NS040925-09 / NINDS NIH HHS R13 NS040925 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000269399200007
- Scopus ID
- 2-s2.0-70349283489
- Other Identifier
- 991021838136804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Pediatrics