Journal article
Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation
Biomaterials, v 26(13), pp 1523-1532
2005
PMID: 15522754
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The anterior cruciate ligament (ACL) is the major intraarticular ligamentous structure of the knee, which functions as a joint stabilizer. It is the most commonly injured ligament of the knee, with over 150,000 ACL surgeries performed annually in the United States. Due to limitations associated with current grafts for ACL reconstruction, there is a significant demand for alternative graft systems. We report here the development of a biodegradable, tissue-engineered ACL graft. Several design parameters including construct architecture, porosity, degradability, and cell source were examined. This graft system is based on polymeric fibers of polylactide-
co-glycolide 10:90, and it was fabricated using a novel, three-dimensional braiding technology. The resultant micro-porous scaffold exhibited optimal pore diameters (175–233
μm) for ligament tissue ingrowth, and initial mechanical properties of the construct approximate those of the native ligament.
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Details
- Title
- Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation
- Creators
- James A. Cooper - University of VirginiaHelen H. Lu - Columbia UniversityFrank K. Ko - Drexel UniversityJoseph W. Freeman - University of VirginiaCato T. Laurencin - University of Virginia
- Publication Details
- Biomaterials, v 26(13), pp 1523-1532
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000226422200009
- Scopus ID
- 2-s2.0-7444268458
- Other Identifier
- 991019168905504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials