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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Fibroblasts Lead the Way: A Unified View of 3D Cell Motility
Trends in cell biology, v 25(11), pp 666-674
Nov 2015
PMID: 26437597
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Primary human fibroblasts are remarkably adaptable, able to migrate in differing types of physiological 3D tissue and on rigid 2D tissue culture surfaces. The crawling behavior of these and other vertebrate cells has been studied intensively, which has helped generate the concept of the cell motility cycle as a comprehensive model of 2D cell migration. However, this model fails to explain how cells force their large nuclei through the confines of a 3D matrix environment and why primary fibroblasts can use more than one mechanism to move in 3D. Recent work shows that the intracellular localization of myosin II activity is governed by cell-matrix interactions to both force the nucleus through the extracellular matrix (ECM) and dictate the type of protrusions used to migrate in 3D.
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Details
- Title
- Fibroblasts Lead the Way: A Unified View of 3D Cell Motility
- Creators
- Ryan J Petrie - National Institute of Dental and Craniofacial ResearchKenneth M Yamada - National Institute of Dental and Craniofacial Research
- Publication Details
- Trends in cell biology, v 25(11), pp 666-674
- Publisher
- Elsevier
- Grant note
- ZIA DE000524-24 / Intramural NIH HHS ZIA DE000718-08 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000364608300006
- Scopus ID
- 2-s2.0-84945532988
- Other Identifier
- 991020100075604721
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- Web of Science research areas
- Cell Biology