Journal article
Fine Needle Aspiration Cytology in Primary Breast Angiosarcoma A Case Report
Acta cytologica, v 54(5), pp 764-770
01 Sep 2010
PMID: 21053536
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Abstract
Background
Angiosarcoma of the breast is an uncommon, aggressive, vascular tumor. The cytomorphologic features of angiosarcomas have rarely been reported.
Case
The present study describes a case of breast angiosarcoma initially diagnosed by fine needle aspiration cytology. Angiosarcoma appeared in the left breast of a 58-year-old woman after 12 years of a mastectomy (without radiotherapy) of the contralateral breast for invasive ductal carcinoma. Fine needle aspiration cytology yielded very bloody material with moderate cellularity. Microscopically, two types of cells were observed: spindle cells and epithelial-like cells with nuclear atypia. The latter were arranged in tight clusters with papillary configuration. Both cell types exhibited immunoreactivity for endothelial markers. The diagnosis of angiosarcoma was confirmed by histopathology of the surgically excised tumor.
Conclusion
Angiosarcoma rarely occurs in the breast, and a definitive diagnosis is extremely difficult relying exclusively on cytologic features. Predominance of epithelioid cells may suggest an epithelial tumor, especially in patients with a history of breast carcinoma, whereas predominance of spindle cells can be misinterpreted as phyllodes tumor or another type of sarcoma. Cell block immunocytochemistry and tumor cell labeling with endothelial markers are necessary for accurate diagnosis. (Acta Cytol 2010;54:764-770)
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Details
- Title
- Fine Needle Aspiration Cytology in Primary Breast Angiosarcoma A Case Report
- Creators
- Sophia Markidou - Diagnost & Therapeut Ctr Athens HYGEIA, Dept Cytopathol, GR-15123 Athens, GreeceIrini Karydas - Diagnost & Therapeut Ctr Athens HYGEIA, Breast Ctr, GR-15123 Athens, GreeceSavvas Papadopoulos - Diagnost & Therapeut Ctr Athens HYGEIA, Dept Pathol, GR-15123 Athens, GreeceIoulia Christodoulidou - Diagnost & Therapeut Ctr Athens HYGEIA, Dept Breast Imaging, GR-15123 Athens, GreeceEvangelia Skarpidi - Diagnost & Therapeut Ctr Athens HYGEIA, Dept Pathol, GR-15123 Athens, GreeceNicoletta Maounis - Sismanoglio Gen Hosp, Dept Clin Cytol, Athens, GreeceMaria Delivoria-Papadopoulos - Pediatrics
- Publication Details
- Acta cytologica, v 54(5), pp 764-770
- Publisher
- Karger
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000283032400003
- Other Identifier
- 991019238586004721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Pathology