Journal article
Fine-Needle Aspiration Cytology of Disseminated Kaposi Sarcoma of the Bone in an AIDS Patient
Acta cytologica, v 59(1), pp 113-117
01 Jan 2015
PMID: 25547261
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Kaposi sarcoma (KS) is a vascular neoplasm associated with human herpesvirus 8 (HHV-8). Skin and mucous membranes are the most common sites, but other organs may be involved. Skeletal KS is rare and occurs either by direct spread of mucocutaneous lesions or through dissemination. Patients present with bone pain and lytic lesions for which they may undergo fine-needle aspiration (FNA). While there are about 70 published case reports of skeletal KS, there is limited literature specifically describing its cytomorphology. Our literature search yielded only a single prior reported case of FNA biopsy of skeletal KS in a Nigerian AIDS patient. Case: We present a case of disseminated KS of the axial skeleton in a 45-year-old African-American man with AIDS which was diagnosed on FNA cytologic examination. The patient presented with multiple lytic lesions in the axial skeleton. The aspirate, core-needle biopsy and touch imprint cytology of a bone lesion demonstrated clusters of spindle and epithelioid cells in radial and streaming arrangement with indistinct intercytoplasmic borders, elongated nuclei, fine chromatin and inconspicuous nucleoli. Immunohistochemical studies revealed positivity for HHV-8 and vascular markers. The cytomorphologic and ancillary features of the case are presented and discussed. (C) 2014 S. Karger AG, Basel
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Details
- Title
- Fine-Needle Aspiration Cytology of Disseminated Kaposi Sarcoma of the Bone in an AIDS Patient
- Creators
- Oleksandr Yergiyev - Allegheny Gen Hosp, Dept Pathol, 320 East North Ave, Pittsburgh, PA 15212 USAAlok Mohanty - Allegheny Gen Hosp, Dept Pathol, 320 East North Ave, Pittsburgh, PA 15212 USASheilah Curran-Melendez - University RadiologyCarmen R. Latona - University RadiologyRama Bhagavatula - Allegheny General HospitalLarisa Greenberg - Allegheny General HospitalJan F. Silverman - Allegheny Gen Hosp, Dept Pathol, 320 East North Ave, Pittsburgh, PA 15212 USA
- Publication Details
- Acta cytologica, v 59(1), pp 113-117
- Publisher
- Karger
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine); General Internal Medicine
- Web of Science ID
- WOS:000421577600017
- Scopus ID
- 2-s2.0-84928423824
- Other Identifier
- 991021931090704721
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- Web of Science research areas
- Pathology