Journal article
Fine Particulate Matter Air Pollution, Proximity to Traffic, and Aortic Atherosclerosis
Epidemiology (Cambridge, Mass.), v 20(2), pp 254-264
01 Mar 2009
PMID: 19129730
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Abstract
Background: The initiation and acceleration of atherosclerosis is hypothesized as a physiologic mechanism underlying associations between air pollution and cardiovascular effects. Despite toxicologic evidence, epidemiologic data are limited.
Methods: In this cross-sectional analysis we investigated exposure to fine particulate matter (PM(2.5)) and residential proximity to major roads in relation to abdominal aortic calcification, a sensitive indicator of systemic atherosclerosis. Aortic calcification was measured by computed tomography among 1147 persons, in 5 US metropolitan areas, enrolled in the Multi-Ethnic Study of Atherosclerosis. The presence and quantity of aortic calcification were modeled using relative risk regression and linear regression, respectively, with adjustment for potential confounders.
Results: We observed a slightly elevated risk of aortic calcification (RR = 1.06; 95% confidence interval = 0.96-1.16) with a 10 mu g/m(3) contrast in PM(2.5). The PM(2.5)-associated risk of aortic calcification was stronger among participants with long-term residence near a PM(2.5) monitor (RR = 1.11; 1.00-1.24) and among participants not recently employed outside the home (RR = 1.10; 1.00-1.22). PM(2.5) was not associated with an increase in the quantity of aortic calcification (Agatston score) and no roadway proximity effects were noted. There was indication of PM(2.5) effect modifidation by lipid-lowering medication use, with greater effects among users, and PM(2.5) associations were observed most consistently among Hispanics.
Conclusions: Although we did not find persuasive associations across our full study population, associations were stronger among participants with less exposure misclassification. These findings support the hypothesis of a relationship between particulate air pollution and systemic atherosclerosis.
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Details
- Title
- Fine Particulate Matter Air Pollution, Proximity to Traffic, and Aortic Atherosclerosis
- Creators
- Ryan W. Allen (Corresponding Author) - Simon Fraser UniversityMichael H. Criqui - University of California San DiegoAna V. Diez Roux - University of MichiganMatthew Allison - University of California San DiegoSteven Shea - Columbia UniversityRobert Detrano - University of California, IrvineLianne Sheppard - University of WashingtonNathan D. Wong - University of California, IrvineKaren Hinckley Stukovsky - University of WashingtonJoel D. Kaufman - University of Washington
- Publication Details
- Epidemiology (Cambridge, Mass.), v 20(2), pp 254-264
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 11
- Grant note
- N01-HC-95159-N01-HC-95161; N01-HC-95163-N01-HC-95165; N01-HC-95169; HL72403 / National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01HC095159 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) P50ES015915 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) ES013195; K24ES013195 / NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R44HL095169 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R830543; R831697 / US EPA; United States Environmental Protection Agency
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000263715400018
- Scopus ID
- 2-s2.0-66149106710
- Other Identifier
- 991020112017104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health