Journal article
Fine Particulate Matter (PM2.5) Air Pollution and Immune Status Among Women in the Seattle Area
Archives of environmental & occupational health, v 66(3), pp 155-165
01 Jan 2011
PMID: 21864104
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Changes in immune status have been suggested as a possible biologic mechanism by which particulatematter (PM) air pollution could lead to adverse health effects. The authors studied associations between ambient PM2.5 and immune status among 115 postmenopausal, overweight women in the greater Seattle, Washington, area. The authors evaluated 3-day, 30-day, and 60-day average PM2.5 values in relation to inflammation markers (C-reactive protein, serum amyloid A, interleukin-6) and functional assays of cellular immunity (natural killer cell cytotoxicity, T-lymphocyte proliferation) at 3 time points for each woman during 1 year. Three-day averaged PM2.5 was inversely associated with anti-CD3-stimulated lymphocyte proliferation. There were no notable associations between the inflammation markers and PM2.5. If additional studies confirm our findings, then future health effect assessments for PM2.5 should consider changes in cellular immunity as an endpoint that may lead to overt clinical disease.
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Details
- Title
- Fine Particulate Matter (PM2.5) Air Pollution and Immune Status Among Women in the Seattle Area
- Creators
- Lori Williams - University of WashingtonCornelia M. Ulrich - University of WashingtonTimothy Larson - University of WashingtonMark H. Wener - University of WashingtonBrent Wood - University of WashingtonZehava Chen-Levy - University of WashingtonPeter T. Campbell - Hutchinson (Canada)John Potter - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaAnne McTiernan - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaAnneclaire J. De Roos - University of Washington
- Publication Details
- Archives of environmental & occupational health, v 66(3), pp 155-165
- Publisher
- Taylor & Francis
- Number of pages
- 11
- Grant note
- CA 69334; DK 02860; DK 035816 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U54 CA116847 / National Cancer Institute initiative on Transdisciplinary Research on Energetics and Cancer (TREC) T32 ES 007262-15 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P30DK035816 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) T32ES007262 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01CA069334 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000299994700004
- Scopus ID
- 2-s2.0-80051558821
- Other Identifier
- 991020100213304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health