Journal article
Fine needle aspiration biopsy of vertebral lesions
Acta cytologica, v 48(1), pp 39-46
01 Jan 2004
PMID: 14969179
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Abstract
OBJECTIVETo evaluate the accuracy of fine needle aspiration biopsy (FNAB) in the diagnosis of vertebral lesions.STUDY DESIGNEighty-nine FNAB cases of vertebral lesions from January 1996 to December 2001 were retrieved from the Allegheny General Hospital laboratory information system. The cases were reviewed and correlated with clinical findings, including previous clinical history, primary site of malignancy and final pathologic diagnosis.RESULTSENAB diagnoses were malignant in 43 cases, benign in 35, suspicious in 1, unsatisfactory in 7 and false negative in 3. Previous clinical history included malignancy (37 patients), osteomyelitis and systemic disease (11), and nonspecific or no history (41). In 34 cases (38.2%) both aspirates and core biopsies were available, and the diagnoses correlated in 29/34 cases (85%). Surgical or core biopsies in the unsatisfactory/suspicious group showed malignancy in 4 cases (50%). The sensitivity of FNAB of vertebral lesions was 96%, specificity 100%, positive predictive value 100% and negative predictive value 92%, with no false positive cases.CONCLUSIONFNAB of vertebral lesions is an effective, sensitive and specific procedure in the diagnostic workup of a patient with or without a prior history of malignancy. Surgical pathology examination, including core biopsies of unsatisfactory or suspicious lesions, can further improve the diagnostic yield.
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Details
- Title
- Fine needle aspiration biopsy of vertebral lesions
- Creators
- Reda S Saad - Allegheny General HospitalKaren M ClaryYulin LiuJan F SilvermanStephen S Raab
- Publication Details
- Acta cytologica, v 48(1), pp 39-46
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000188470800008
- Scopus ID
- 2-s2.0-0842305752
- Other Identifier
- 991019168841104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pathology