Journal article
Fine particulate matter and incident coronary heart disease in the REGARDS cohort
The American heart journal, v 197, pp 94-102
22 Nov 2017
PMID: 29447790
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic exposure to fine particulate matter (PM
2.5
) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of the effect of chronic exposure to PM
2.5
on risk for CHD do not generalize to more diverse samples. Therefore, we estimated the relationship between chronic exposure to PM
2.5
and risk for CHD in among participants in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort who were free from CHD at baseline (n = 17,126). REGARDS is a sample of whites and blacks of both genders living across the continental US. We fit Cox proportional hazards models for time to CHD to estimate the hazard ratio (HR) for baseline 1-year mean PM
2.5
exposure, adjusting for environmental variables, demographics, and other risk factors for CHD including the Framingham Risk Score (FRS). The HR (95% confidence interval) for a 2.7 μg/m
3
increase (interquartile range) 1-year mean concentration of PM
2.5
was 0.94 (0.83, 1.06) for combined CHD death and nonfatal MI, 1.13 (0.92, 1.40) for CHD death, and 0.85 (0.73, 0.99) for nonfatal MI. We also did not find evidence that these associations depended upon overall CHD risk factor burden. Our results do not provide strong evidence for an association between PM
2.5
and incident CHD in a heterogeneous cohort, and we conclude that the effects of chronic exposure to fine particulate matter on CHD require further evaluation.
Metrics
Details
- Title
- Fine particulate matter and incident coronary heart disease in the REGARDS cohort
- Creators
- Matthew Shane Loop - University of North Carolina at Chapel HillLeslie A. McClure - Drexel UniversityEmily B. Levitan - University of Alabama at BirminghamMohammad Z. Al-Hamdan - Marshall Space Flight CenterWilliam L. Crosson - Marshall Space Flight CenterMonika M. Safford - Cornell University
- Publication Details
- The American heart journal, v 197, pp 94-102
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000425723700012
- Scopus ID
- 2-s2.0-85039980788
- Other Identifier
- 991019168211604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems