Journal article
First-trimester maternal plasma cytokine levels, pre-pregnancy body mass index, and spontaneous preterm delivery
Acta obstetricia et gynecologica Scandinavica, v 88(3), pp 332-342
01 Jan 2009
PMID: 19241227
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. To examine associations between first-trimester plasma cytokines and spontaneous preterm delivery (sPTD). Design. A case-control study was nested within the Danish National Birth Cohort, a cohort of women with 101,042 pregnancies from 1997 to 2002 who were recruited during pregnancy and followed prospectively. Sample. Subjects included 107 women delivering singleton infants at 24-29 weeks, 353 at 30-33 weeks, 422 at 34-36 weeks, and 1,372 at 37 weeks. Methods. Maternal plasma interleukin (IL)-2, IL-6, tumor necrosis factor (TNF)-, interferon (IFN)-, and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured at a median of eight weeks gestation using multiplex flow cytometry. Adjusted odds ratios (ORs) were obtained using polytomous logistic regression. Main outcome measures. sPTD categorized as: 24-29 weeks, 30-33 weeks, 34-36 weeks, and 37 weeks (controls). Results. Elevated TNF- and GM-CSF were associated with an increased risk of delivery at 34-36 weeks. In underweight women, sPTD 34 weeks was associated with elevated (75th percentile) IL-6 (OR=5.62, 95% confidence interval (CI): 1.73, 18.26) and TNF- (OR=3.02, CI: 1.02, 8.91) compared with term delivery. Conversely, among obese women, elevated IL-2 (OR=0.30, CI: 0.11, 0.78) and TNF- (OR=0.15, CI: 0.05, 0.47) were associated with a reduced risk of delivering at 34 weeks. Cytokines were not related to delivery at 34 weeks in normal-weight and overweight women. Conclusions. These findings suggest that the association between first-trimester plasma cytokine levels and sPTD may depend on pre-pregnancy body mass index.
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Details
- Title
- First-trimester maternal plasma cytokine levels, pre-pregnancy body mass index, and spontaneous preterm delivery
- Creators
- Allison Elizabeth Curry - Emory UniversityPoul Thorsen - Emory UniversityCarolyn Drews - Emory UniversityDiana Schendel - National Center on Birth Defects and Developmental DisabilitiesKristin Skogstrand - Aarhus UniversityWilliam Dana Flanders - Emory UniversityDavid Hougaard - Statens Serum InstitutJorn OlsenIda Vogel - Aarhus University
- Publication Details
- Acta obstetricia et gynecologica Scandinavica, v 88(3), pp 332-342
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- 20-FY0328 / March of Dimes UR3/CCU018305-03 / CDC Cooperative Agreement; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA American Women in Science Fellowship
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000263704300016
- Scopus ID
- 2-s2.0-60849119286
- Other Identifier
- 991021463430704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology