Journal article
Five-year Trends In Outcomes Of Congenital Heart Disease Patients Undergoing Heart Transplantation
Journal of cardiac failure, v 31(1), pp 213-213
Jan 2025
Abstract
Congenital heart diseases (CHD) are the most common congenital anomalies diagnosed at birth. The prevalence of CHD has been steadily increasing over the decades. Most patients are surviving into adolescence and adulthood because of improved surgical techniques. However, a wide range of hemodynamic abnormalities can lead to heart failure. Increasingly, CHD patients with advanced heart failure are undergoing heart transplants. This study is to assess national trends in outcomes of CHD patients undergoing heart transplantation (HTx).
This is a retrospective cohort analysis using 2016 to 2020 National Inpatient Sample. The International Classification of Diseases, Tenth Revision (ICD- 10) clinical modification codes were used to identify all congenital heart disease patients undergoing HTx. The outcomes assessed were in-hospital mortality and associated complications. Pearson Chi-square and t-test were used for data analysis.
We identified 358 hospitalizations with CHD that underwent HTx in the USA from 2016 to 2020. The rate of hospitalizations for CHD undergoing HTx from 2016 to 2020 was similar with a range from 18% to 22% (p=0.738). The majority of CHD and HTx hospitalizations were in male (61% vs 39%, p<0.001). The predominant racial distributions were Whites (61%) and Hispanics (21%). The vast majority of heart transplants in CHD were performed in urban teaching hospitals, compared to rural hospitals (99% vs 0%, p<0.001). Our analysis showed that the total overall in-hospital mortality was 6.2% and there was no significant change from 2016 (4.2%) to 2020 (4.2%) (p=0.202), except for 12.5% in 2017. The rates of major complications were ventricular tachycardia or fibrillation (20%), respiratory complications with acute respiratory failure (0.3%), acute kidney failure requiring dialysis (5.3%) and post operative bleeding (5%) with no change in the annual trend from 2016 to 2020 (p-trend >0.05).
Over a five-year period from 2016 to 2020, there was no change in volumes of HTx in CHD along with no statistical difference in in-hospital mortality. The major postoperative complications rates overall remained unchanged.
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Details
- Title
- Five-year Trends In Outcomes Of Congenital Heart Disease Patients Undergoing Heart Transplantation
- Creators
- Khaing Khaing Htwe - McLaren Flint/Michigan State University, Flint, MINischit Baral - Mount Sinai Medical CenterKhurram Arshad - Corewell HealthHtay Aung - St. Christopher's Hospital for ChildrenAhmad Munir - McLaren Flint/Michigan State University, Flint, MI
- Publication Details
- Journal of cardiac failure, v 31(1), pp 213-213
- Publisher
- Elsevier Inc
- Number of pages
- 1
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Other Identifier
- 991022047142204721