Journal article
Floating electrode dielectric barrier discharge plasma in air promoting apoptotic behavior in melanoma skin cancer cell lines
Plasma chemistry and plasma processing, v 27(2), pp 163-176
01 Apr 2007
Abstract
Initiation of apoptosis, or programmed cell death, is an important issue in cancer treatment as cancer cells frequently have acquired the ability to block apoptosis and thus are more resistant to chemotherapeutic drugs. Targeted and perhaps selective destruction of cancerous tissue is desirable for many reasons, ranging from the enhancement of or aid to current medical methods to problems currently lacking a solution, i.e., lung cancer. Demonstrated in this publication is the inactivation (killing) of human Melanoma skin cancer cell lines, in vitro, by Floating Electrode Dielectric Barrier Discharge (FE-DBD) plasma. Not only are these cells shown to be killed immediately by high doses of plasma treatment, but low doses are shown to promote apoptotic behavior as detected by TUNEL staining and subsequent flow cytometry. It is shown that plasma acts on the cells directly and not by "poisoning" the solution surrounding the cells, even through a layer of such solution. Potential mechanisms of interaction of plasma with cells are discussed and further steps are proposed to develop an understanding of such systems.
Metrics
Details
- Title
- Floating electrode dielectric barrier discharge plasma in air promoting apoptotic behavior in melanoma skin cancer cell lines
- Creators
- Gregory FridmanAlexey ShereshevskyMonika M. Jost - Drexel University, Pathology (and Laboratory Medicine)Ari D. Brooks - Drexel UniversityAlexander Fridman - Drexel University, Mechanical Engineering and MechanicsAlexander Gutsol - Drexel UniversityVictor VasiletsGary Friedman - Drexel University, C. and J. Nyheim Plasma Institute
- Publication Details
- Plasma chemistry and plasma processing, v 27(2), pp 163-176
- Publisher
- Springer Nature
- Number of pages
- 14
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; C. and J. Nyheim Plasma Institute; Mechanical Engineering and Mechanics; Intensive Medical Sciences (IMS); Pathology (and Laboratory Medicine); Surgery
- Web of Science ID
- WOS:000245134800004
- Scopus ID
- 2-s2.0-33947696131
- Other Identifier
- 991014632182404721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Chemical
- Physics, Applied
- Physics, Fluids & Plasmas