Journal article
Fluorescent PLLA-nanodiamond composites for bone tissue engineering
Biomaterials, v 32(1), pp 87-94
2011
PMID: 20869765
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Superior mechanical properties, rich surface chemistry, and good biocompatibility of diamond nanoparticles make them attractive in biomaterial applications. A multifunctional fluorescent composite bone scaffold material has been produced utilizing a biodegradable polymer, poly(
l-lactic acid) (PLLA), and octadecylamine-functionalized nanodiamond (ND-ODA). The uniform dispersion of nanoparticles in the polymer led to significant increase in hardness and Young’s modulus of the composites. Addition of 10%wt of ND-ODA resulted in more than 200% increase in Young’s modulus and 800% increase in hardness, bringing the nanocomposite properties close to that of the human cortical bone. Testing of ND-ODA/PLLA as a matrix supporting murine osteoblast (7F2) cell growth for up to 1 week showed that the addition of ND-ODA had no negative effects on cell proliferation. ND-ODA serves as a multifunctional additive providing improved mechanical properties, bright fluorescence, and options for drug loading and delivery
via surface modification. Thus ND-ODA/PLLA composites open up numerous avenues for their use as components of bone scaffolds and smart surgical tools such as fixation devices in musculoskeletal tissue engineering and regenerative medicine. Intense fluorescence of ND-ODA/PLLA scaffolds can be used to monitor bone re-growth replacing the implant
in vivo.
Metrics
Details
- Title
- Fluorescent PLLA-nanodiamond composites for bone tissue engineering
- Creators
- Qingwei Zhang - Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA 19104, USAVadym N Mochalin - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USAIoannis Neitzel - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USAIsabel Y Knoke - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USAJingjia Han - School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104, USAChristopher A Klug - Naval Research Laboratory, Chemistry Division, Washington, DC 20375, USAJack G Zhou - Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA 19104, USAPeter I Lelkes - Surgical Engineering Enterprise, College of Medicine, Drexel University, Philadelphia, PA 19102, USAYury Gogotsi - Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA 19104, USA
- Publication Details
- Biomaterials, v 32(1), pp 87-94
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000285217600011
- Scopus ID
- 2-s2.0-78349311451
- Other Identifier
- 991014878418704721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials