Journal article
Fluoride exposure and pubertal development in children living in Mexico City
Environmental health, v 18(1), pp 26-26
29 Mar 2019
PMID: 30922319
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundPrevious animal and ecological studies have provided evidence for an earlier sexual maturation in females in relation to fluoride exposure; however, no epidemiological studies have examined the association between fluoride exposure and pubertal development in both boys and girls using individual-level biomarkers of fluoride. Capitalizing on an ongoing Mexican birth cohort study, we examined the association between concurrent urinary fluoride levels and physical markers of pubertal development in children.MethodsWe conducted a cross-sectional study of 157 boys and 176 girls at age 10-17years living in Mexico City. We used ion-selective electrode-based diffusion methods to assess fluoride levels in urine, adjusting for urinary specific gravity. Pubertal stages were evaluated by a trained physician. Associations of fluoride with pubertal stages and age at menarche were studied using ordinal regression and Cox proportional-hazard regression, respectively.ResultsIn the entire sample, the geometric mean and interquartile range (IQR) of urinary fluoride (specific gravity adjusted) were 0.59mg/L and 0.31mg/L, respectively. In boys, our analysis showed that a one-IQR increase in urinary fluoride was associated with later pubic hair growth (OR=0.71, 95% CI: 0.51-0.98, p=0.03) and genital development (OR=0.71, 95% CI: 0.53-0.95, p=0.02). No significant associations were found in girls, although the direction was negative.ConclusionsChildhood fluoride exposure, at the levels observed in our study, was associated with later pubertal development among Mexican boys at age 10-17years. Further research is needed to confirm these findings.
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Details
- Title
- Fluoride exposure and pubertal development in children living in Mexico City
- Creators
- Yun Liu - University of MichiganMartha Tellez-Rojo - National Institute of Public HealthHoward Hu - University of TorontoBrisa N. Sanchez - University of MichiganE. Angeles Martinez-Mier - Indiana University – Purdue University IndianapolisNiladri Basu - McGill UniversityAdriana Mercado-Garcia - National Institute of Public HealthMaritsa Solano-Gonzalez - National Institute of Public HealthKaren E. Peterson - University of Michigan
- Publication Details
- Environmental health, v 18(1), pp 26-26
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- R01ES021446; R01ES007821 / U.S. National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Institute of Public Health/Ministry of Health of Mexico P01ES022844 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P01ES022844 / National Institute of Environmental Health Sciences/the U.S. Environmental Protection Agency P20ES018171 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000463820500002
- Scopus ID
- 2-s2.0-85063744522
- Other Identifier
- 991020100195704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health