Journal article
Focal seizure propagation in the intracranial EEG
Epilepsy research, Vol.93(1)
2011
PMID: 21130604
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intracranial EEG offers a unique opportunity to study epileptic seizures in humans. Seizure propagation has not been extensively studied. We aimed to compare the propagation of focal seizures with onset in different brain regions.
Seven zones were defined as medial frontal (MF), dorsolateral frontal (DLF), orbitofrontal (OF), medial temporal (MF), lateral temporal (LT), parietal (P) and occipital (O). Routes and times of ipsilateral (IPT) and contralateral (CPT) propagation as well as ictal frequency in onset zone and propagation zone were compared.
Forty patients had 112 seizures. (Mean and median number of seizures per zone was 16 and 15). Preferred routes of propagation, based on ictal onset, were: MF to contralateral MF; DLF to ispilateral temporal lobe; OF to contralateral OF and ispilateral temporal lobe; MT to contralateral MT; LT to ispilateral MT and OF and contralateral LT and MT; P to ispilateral temporal lobe, DLF and O; O to ipsilateral MT. IPT and CPT varied markedly between zones. Ictal onset frequency was faster than propagated frequency.
Seizure propagation varies according to onset zone possibly following major pathways. This needs confirmation. The findings could aid in the interpretation of symptoms and EEG and may result useful for future treatment using brain stimulation or disconnective surgery. The limitations are clearly stated.
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Details
- Title
- Focal seizure propagation in the intracranial EEG
- Creators
- Sigmund Jenssen - Delaware County Memorial Hospital, 2100 Keystone Avenue, Drexel Hill, PA 19026, United StatesColin M Roberts - Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United StatesEdward J Gracely - Drexel University College of Medicine, Department of Family, Community and Preventive Medicine, 2900 Queen Lane, Philadelphia, PA 19129, United StatesDennis J Dlugos - The Children's Hospital of Pennsylvania, 6th Floor, Wood Building, Philadelphia, PA 19104, United StatesMichael R Sperling - Jefferson Hospital for Neurosciences, 900 Walnut St, Philadelphia, PA 19107, United States
- Publication Details
- Epilepsy research, Vol.93(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology; MD (Doctor of Medicine) Program
- Identifiers
- 991014878021604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology