Journal article
Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective
Frontiers in immunology, v 9, pp 895-895
18 Jun 2018
PMID: 29967602
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Effective antiretroviral therapy (ART) has prevented the progression to AIDS and reduced HIV-related morbidities and mortality for the majority of infected individuals. However, a lifelong administration of ART is necessary, placing an inordinate burden on individuals and public health systems. Therefore, discovering therapeutic regimens able to eradicate or functionally cure HIV infection is of great importance. ART interruption leads to viral rebound highlighting the establishment and maintenance of a latent viral reservoir compartment even under long-term treatment. Follicular helper CD4 T cells (TFH) have been reported as a major cell compartment contributing to viral persistence, consequent to their susceptibility to infection and ability to release replication-competent new virions. Here, we discuss the molecular profiles and potential mechanisms that support the role of TFH cells as one of the major HIV reservoirs.
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Details
- Title
- Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective
- Creators
- Malika Aid - Beth Israel Deaconess Medical CenterFrank P. Dupuy - Centre Hospitalier de l’Université de MontréalEirini Moysi - CoreSusan Moir - National Institute of Allergy and Infectious DiseasesElias K. Haddad - Drexel UniversityJacob D. Estes - Oregon National Primate Research CenterRafick Pierre Sekaly - Case Western Reserve UniversityConstantinos Petrovas - CoreSusan Pereira Ribeiro - Case Western Reserve University
- Publication Details
- Frontiers in immunology, v 9, pp 895-895
- Publisher
- Frontiers Media Sa
- Number of pages
- 8
- Grant note
- OP1032325 / Collaboration for AIDS Vaccine Discovery from the Bill and Melinda Gates Foundation R01 AI134419; R21/R33 AI 122380-01 / NIH/NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01AI134419 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Intramural Research Program of the Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000435492000001
- Scopus ID
- 2-s2.0-85048602579
- Other Identifier
- 991020099212504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology