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Journal article
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production
The Journal of experimental medicine, v 210(1), pp 143-156
14 Jan 2013
PMID: 23254284
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the present study, we have investigated the distribution of HIV-specific and HIV-infected CD4 T cells within different populations of memory CD4 T cells isolated from lymph nodes of viremic HIV-infected subjects. Four memory CD4 T cell populations were identified on the basis of the expression of CXCR5, PD-1, and Bcl-6: CXCR5−PD-1−Bcl-6−, CXCR5+PD-1−Bcl-6−, CXCR5−PD-1+Bcl-6−, and CXCR5+PD-1+Bcl-6+. On the basis of Bcl-6 expression and functional properties (IL-21 production and B cell help), the CXCR5+PD-1+Bcl-6+ cell population was considered to correspond to the T follicular helper (Tfh) cell population. We show that Tfh and CXCR5−PD-1+ cell populations are enriched in HIV-specific CD4 T cells, and these populations are significantly increased in viremic HIV-infected subjects as compared with healthy subjects. The Tfh cell population contained the highest percentage of CD4 T cells harboring HIV DNA and was the most efficient in supporting productive infection in vitro. Replication competent HIV was also readily isolated from Tfh cells in subjects with nonprogressive infection and low viremia (<1,000 HIV RNA copies). However, only the percentage of Tfh cells correlated with the levels of plasma viremia. These results demonstrate that Tfh cells serve as the major CD4 T cell compartment for HIV infection, replication, and production.
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Details
- Title
- Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production
- Creators
- Matthieu Perreau - National Institute of Allergy and Infectious DiseasesAnne-Laure Savoye - National Institute of Allergy and Infectious DiseasesElisa De Crignis - National Institute of Allergy and Infectious DiseasesJean-Marc Corpataux - National Institute of Allergy and Infectious DiseasesRafael Cubas - Vaccine & Gene Therapy Institute of FloridaElias K. Haddad - Vaccine & Gene Therapy Institute of FloridaLaurence De Leval - National Institute of Allergy and Infectious DiseasesCecilia Graziosi - National Institute of Allergy and Infectious DiseasesGiuseppe Pantaleo - National Institute of Allergy and Infectious Diseases
- Publication Details
- The Journal of experimental medicine, v 210(1), pp 143-156
- Publisher
- The Rockefeller University Press
- Number of pages
- 14
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000313560900013
- Scopus ID
- 2-s2.0-84874519282
- Other Identifier
- 991020100059004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental