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Food cue reactivity in food addiction: A functional magnetic resonance imaging study
Journal article   Open access   Peer reviewed

Food cue reactivity in food addiction: A functional magnetic resonance imaging study

Erica M. Schulte, Sonja Yokum, Andrew Jahn and Ashley N. Gearhardt
Physiology & behavior, v 208, 112574
01 Sep 2019
DOI: https://doi.org/10.1016/j.physbeh.2019.112574
PMID: 31181233
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620138View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Addiction Eating disorders fMRI Food addiction Obesity Overweight
While neuroimaging studies have revealed that reward dysfunction may similarly contribute to obesity and addiction, no prior studies have examined neural responses in individuals who meet the “clinical” food addiction phenotype. Women (n = 44) with overweight and obesity, nearly half of whom (n = 20) met criteria for moderate-to-severe Yale Food Addiction Scale 2.0 (YFAS 2.0) food addiction, participated in a functional magnetic resonance imaging cue reactivity task. Participants viewed images of highly processed foods, minimally processed foods, and household objects while thinking about how much they wanted each item. Differences in neural responses by YFAS 2.0 food addiction to highly processed and minimally processed food cues were investigated. There was a significant interaction between participant group and neural response in the right superior frontal gyrus to highly versus minimally processed food cues (r = 0.57). Individuals with YFAS 2.0 food addiction exhibited modest, elevated responses in the superior frontal gyrus for highly processed food images and more robust, decreased activations for minimally processed food cues, whereas participants in the control group showed the opposite responses in this region. Across all participants, the household items elicited greater activation than the food cues in regions associated with interoceptive awareness and visuospatial attention (e.g., insula, inferior frontal gyrus, inferior parietal lobe). Women with overweight or obesity and YFAS 2.0 food addiction, compared to those with only overweight or obesity, exhibited differential responses to highly and minimally processed food cues in a region previously associated with cue-induced craving in persons with a substance-use disorder. Overall, the present work provides further support for the utility of the food addiction phenotype within overweight and obesity. •fMRI investigated differences in neural responses to highly and minimally processed food cues by food addiction (FA).•Persons with FA exhibited differential responses to highly and minimally processed food cues in the superior frontal gyrus.•Greater neural response in this region has been observed in persons with a substance-use disorder in response to drug cues.•Craving-related neural activation may contribute to the addictive consumption of highly processed foods for those with FA.

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65 citations in Web of Science
65 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being
#5 Gender Equality

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Collaboration types
Domestic collaboration
Web of Science research areas
Behavioral Sciences
Psychology, Biological
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