Journal article
Food-related stimuli increase the ratio of 3,4-dihydroxyphenylacetic acid to dopamine in the hypothalamus
Pharmacology, biochemistry and behavior, v 23(2), 253
Aug 1985
PMID: 4059311
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rats were restricted for three weeks to a schedule of 4-hr daily access to food. The regional concentrations of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the forebrain were then determined after the rats: (1) were food-deprived overnight; (2) ate for the first hour of the scheduled feeding period; or (3) remained in their cages without receiving food but while other rats fed. A group of controls had food available continuously. The DOPAC/DA ratio, a metabolic index of DA activity, increased in the hypothalamus of rats that fed and in the rats exposed to food-related stimuli without eating. This ratio did not change in the striatum, olfactory tubercle, amygdala-pyriform lobe or nucleus accumbens. Furthermore, this index did not differ from controls in any region of the forebrain in deprived rats that were not exposed to stimuli signalling the availability of food. Together, these data suggest that environmental stimuli associated with feeding after deprivation, and not the act of feeding, increased dopaminergic activity in the hypothalamus.
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Details
- Title
- Food-related stimuli increase the ratio of 3,4-dihydroxyphenylacetic acid to dopamine in the hypothalamus
- Creators
- Kenny J. Simansky - NewYork–Presbyterian HospitalKathy A. Bourbonais - NewYork–Presbyterian HospitalGerard P. Smith - Cornell University
- Publication Details
- Pharmacology, biochemistry and behavior, v 23(2), 253
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Web of Science ID
- WOS:A1985APX4200018
- Scopus ID
- 2-s2.0-0022357220
- Other Identifier
- 991021842530104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy