Journal article
Force generation by cytoskeletal motor proteins as a regulator of axonal elongation and retraction
Trends in cell biology, v 11(6)
2001
PMID: 11356360
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Axons elongate and retract in response to environmental signals during the development of the nervous system. There is broad agreement that these signals must affect the cytoskeleton to elicit bouts of elongation or retraction. Most contemporary studies have speculated that bouts of elongation involve polymerization of the cytoskeleton whereas bouts of retraction involve depolymerization of the cytoskeleton. Here we present an alternative view, namely that molecular motor proteins generate forces on the cytoskeletal polymers that can affect their distribution and configuration. In this view, bouts of axonal elongation involve net forward movement of cytoskeletal elements whereas bouts of retraction involve net backward movements. We propose that environmental cues elicit bouts of elongation or retraction via biochemical pathways that modulate the activities of relevant motors.
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Details
- Title
- Force generation by cytoskeletal motor proteins as a regulator of axonal elongation and retraction
- Creators
- Peter W BaasFridoon J Ahmad
- Publication Details
- Trends in cell biology, v 11(6)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000168717800008
- Scopus ID
- 2-s2.0-0035371886
- Other Identifier
- 991014878143104721
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- Web of Science research areas
- Cell Biology