Journal article
Forced Expiratory Time and Bronchial Hyperresponsiveness to Methacholine
The Journal of asthma, v 39(2), pp 143-150
2002
PMID: 11990229
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pulmonary function tests (PFTs) are normally performed prior to methacholine inhalation challenges (MICs). In contrast to normal baseline spirometry (FEV1, FEF25%-27%, FVC), we have observed patients with positive MICs having shortened forced expiratory times (FET100%) in the baseline pre-MIC PFT. We prospectively evaluated the correlation of abnormalities in baseline pre-MIC FET100% in patients who have positive vs. negative MICs. Prospective analysis of baseline pre-MIC FET100% and MIC results in suspected asthmatics with normal lung exams, spirometry and chest x-rays. Using a PC20 FEV1 of ≤ 8 mg ml methacholine, there were 115 positive and 69 negative MICs. The mean (±1 SD) FET100% in the positive MIC group was 3.57 ± 1.68 sec vs. 4.73 ± 1.60 sec in the negative group. The difference in these means was statistically significant (p < 0.0001). There was a statistically significant difference in the incidence of FET100% < 4 sec in the positive (55.65%) vs. the negative (30.43%) MIC group, p < 0.001. There was also a statistically significant difference in the incidence of positive MIC in FET100% < 4 sec (75.29%) vs. FET100% ≥ 4 sec (51.52%), p < 0.001. Our results suggest that in our highly selected, well-characterized population, FET100% < 6 sec is common and FET100% < 4 sec correlates with an increased likelihood of having a positive MIC.
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Details
- Title
- Forced Expiratory Time and Bronchial Hyperresponsiveness to Methacholine
- Creators
- Marc F. Goldstein - Department of Medicine and Pediatrics, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, USA.Bernadette A. Veza - Hahnemann University HospitalArlene Lauf-Goldstein - Private Practice in Psychology, 467 Egg Harbor Road, Sewell, New Jersey, U.S.A.Donald J. Dvorin - Department of Medicine and Pediatrics, Allergy and Immunology Division, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, U.S.A.Eliot H. Dunsky - Department of Medicine and Pediatrics, Allergy and Immunology Division, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, U.S.A.George A. Belecanech - Department of Medicine and Pediatrics, Allergy and Immunology Division, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, U.S.A.
- Publication Details
- The Journal of asthma, v 39(2), pp 143-150
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine; Obstetrics and Gynecology
- Web of Science ID
- WOS:000175213200006
- Scopus ID
- 2-s2.0-0036236187
- Other Identifier
- 991019168128404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Allergy
- Respiratory System