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Journal article
Forelimb movements contribute to hindlimb cutaneous reflexes during locomotion in cats
Journal of neurophysiology, v 131(6), pp 997-1013
Jun 2024
PMID: 38691528
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
During quadrupedal locomotion, interactions between spinal and supraspinal circuits and somatosensory feedback coordinate forelimb and hindlimb movements. How this is achieved is not clear. To determine if forelimb movements modulate hindlimb cutaneous reflexes involved in responding to an external perturbation, we stimulated the superficial peroneal nerve in six intact cats during quadrupedal locomotion and during hindlimb-only locomotion (with forelimbs standing on stationary platform) and in two cats with a low spinal transection (T12-T13) during hindlimb-only locomotion. We compared cutaneous reflexes evoked in six ipsilateral and four contralateral hindlimb muscles. Results showed similar occurrence and phase-dependent modulation of short-latency inhibitory and excitatory responses during quadrupedal and hindlimb-only locomotion in intact cats. However, the depth of modulation was reduced in the ipsilateral semitendinosus during hindlimb-only locomotion. Additionally, longer-latency responses occurred less frequently in extensor muscles bilaterally during hindlimb-only locomotion while short-latency inhibitory and longer-latency excitatory responses occurred more frequently in the ipsilateral and contralateral sartorius anterior, respectively. After spinal transection, short-latency inhibitory and excitatory responses were similar to both intact conditions, while mid- or longer-excitatory responses were reduced or abolished. Our results in intact cats and the comparison with spinal-transected cats suggest that the absence of forelimb movements suppresses inputs from supraspinal structures and/or cervical cord that normally contribute to longer-latency reflex responses in hindlimb extensor muscles.
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- Title
- Forelimb movements contribute to hindlimb cutaneous reflexes during locomotion in cats
- Creators
- Jonathan Harnie - Université de SherbrookeRasha Al Arab - Université de SherbrookeStephen Mari - Université de SherbrookeSirine Yassine - Université de SherbrookeOussama Eddaoui - Université de SherbrookePierre Jéhannin - Université de SherbrookeJohannie Audet - Université de SherbrookeCharly Lecomte - Université de SherbrookeChristian Iorio-Morin - Université de SherbrookeBoris I Prilutsky - Georgia Institute of TechnologyIlya A Rybak - Drexel UniversityAlain Frigon - Université de Sherbrooke
- Publication Details
- Journal of neurophysiology, v 131(6), pp 997-1013
- Publisher
- American Physiological Society
- Grant note
- R01 NS110550 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001252659000008
- Scopus ID
- 2-s2.0-85194975881
- Other Identifier
- 991021875514904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Physiology