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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Forelimb muscle plasticity following unilateral cervical spinal cord injury
Muscle & nerve, v 53(3), pp 475-478
Mar 2016
PMID: 26662579
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Motor dysfunction and muscle atrophy are well documented in the lower extremity after spinal cord injury. However, the extent and time course of myoplastic changes in forelimb musculature is not clear.
Forelimb muscle morphology and fiber type were evaluated after high cervical hemilesion injury in rats.
There was significant atrophy of the ipsilateral extensor carpi radialis longus (ECRL) muscle at 2 weeks postinjury, which was subsequently reversed at 8 weeks postinjury. The triceps muscle showed minimal evidence of atrophy after spinal injury. No significant changes in fiber type were observed.
These findings indicate a robust capacity for spontaneous myoplasticity after C2 hemisection injury but highlight differential capacity for plasticity within the forelimb muscles.
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Details
- Title
- Forelimb muscle plasticity following unilateral cervical spinal cord injury
- Creators
- Elisa J Gonzalez-Rothi - McKnight Brain InstituteGregory T Armstrong - McKnight Brain InstituteAnthony J Cerreta - McKnight Brain InstituteGarrett M Fitzpatrick - McKnight Brain InstitutePaul J Reier - McKnight Brain InstituteMichael A Lane - McKnight Brain InstituteAndrew R Judge - McKnight Brain InstituteDavid D Fuller - McKnight Brain Institute
- Publication Details
- Muscle & nerve, v 53(3), pp 475-478
- Publisher
- Wiley
- Grant note
- NS80180 / NINDS NIH HHS T32 HD043730 / NICHD NIH HHS R01 NS080180 / NINDS NIH HHS 1R01-HD-052682 / NICHD NIH HHS UL1 TR001427 / NCATS NIH HHS K12 HD055929 / NICHD NIH HHS R01 HD052682 / NICHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000369837200021
- Scopus ID
- 2-s2.0-84956946218
- Other Identifier
- 991019168713004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences