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Journal article
Forskolin Modulates Acetylcholine Receptor Gating by Interacting with the Small Extracellular Loop Between the M2 and M3 Transmembrane Domains
Cellular and molecular neurobiology, v 20(5), pp 569-577
Oct 2000
PMID: 10930133
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Abstract
1. Forskolin acts as an allosteric modulator of muscle-type nicotinic acetylcholine receptors. Receptors from mouse muscle and Torpedo electroplax demonstrate differential sensitivity to inhibition by forskolin. Previous work from this laboratory suggested that the γ subunit is responsible for this differential sensitivity.2. We have used a series of mouse/Torpedo species-chimeric γ subunits to further define the site of forskolin interaction with the γ subunit. Analysis of the patterns of forskolin inhibition of receptors containing mouse/Torpedo chimeric γ subunits along with the mouse α, β, and δ subunits suggests that forskolin interacts with the small extracellular domain that links the M2 and M3 transmembrane domains (the M2–M3 linker).3. We suggest that the M2–M3 linker domain plays an important role in the transduction of ligand binding to the conformational changes that result in channel opening.
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Details
- Title
- Forskolin Modulates Acetylcholine Receptor Gating by Interacting with the Small Extracellular Loop Between the M2 and M3 Transmembrane Domains
- Creators
- Zhaoming Chen - Department of Pharmacology and Physiology MCP Hahnemann University Philadelphia Pennsylvania 19129Michael White - Department of Pharmacology and Physiology MCP Hahnemann University Philadelphia Pennsylvania 19129
- Publication Details
- Cellular and molecular neurobiology, v 20(5), pp 569-577
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000088238300004
- Scopus ID
- 2-s2.0-0034297331
- Other Identifier
- 991014878091604721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Neurosciences