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Journal article
Fractionated Stereotactic Radiotherapy for Facial Nerve Schwannomas
Journal of neurological surgery. Part B, Skull base, v 77(1), pp 75-80
01 Feb 2016
PMID: 26949592
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose
Data on the clinical course of irradiated facial nerve schwannomas (FNS) are lacking. We evaluated fractionated stereotactic radiotherapy (FSRT) for FNS.
Methods
Eight consecutive patients with FNS treated at our institution between 1998 and 2011 were included. Patients were treated with FSRT to a median dose of 50.4 Gy (range: 46.8–54 Gy) in 1.8 or 2.0 Gy fractions. We report the radiographic response, symptom control, and toxicity associated with FSRT for FNS.
Results
The median follow-up time was 43 months (range: 10–75 months). All patients presented with symptoms including pain, tinnitus, facial asymmetry, diplopia, and hearing loss. The median tumor volume was 1.57 cc. On the most recent follow-up imaging, five patients were noted to have stable tumor size; three patients had a net reduction in tumor volume. Additionally, six patients had improvement in clinical symptoms, one patient had stable clinical findings, and one patient had worsened House-Brackmann grade due to cystic degeneration.
Conclusion
FSRT treatment of FNS results in excellent control of growth and symptoms with a small rate of radiation toxicity. Given the importance of maintaining facial nerve function, FSRT could be considered as a primary management modality for enlarging or symptomatic FNS.
Metrics
Details
- Title
- Fractionated Stereotactic Radiotherapy for Facial Nerve Schwannomas
- Creators
- Wenyin Shi - Thomas Jefferson UniversityVarsha Jain - University of PennsylvaniaHyun Kim - Thomas Jefferson UniversityColin Champ - UPMC Hillman Cancer CenterGaurav Jain - Thomas Jefferson UniversityChristopher Farrell - Thomas Jefferson UniversityDavid W. Andrews - Thomas Jefferson UniversityKevin Judy - Thomas Jefferson UniversityHaisong Liu - Thomas Jefferson UniversityGregory Artz - Thomas Jefferson UniversityMaria Werner-Wasik - Thomas Jefferson UniversityJames J. Evans - Thomas Jefferson University
- Publication Details
- Journal of neurological surgery. Part B, Skull base, v 77(1), pp 75-80
- Publisher
- Georg Thieme Verlag KG
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000375047000012
- Scopus ID
- 2-s2.0-84960090126
- Other Identifier
- 991021897255004721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery