Journal article
Fracture behavior of human cortical bone: Role of advanced glycation end-products and microstructural features
Journal of biomechanics, v 125, 110600
26 Aug 2021
PMID: 34246065
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Diabetes is associated with increased fracture risk in human bone, especially in the elderly population. In the present study, we investigate how simulated advanced glycation end-products (AGEs) and materials heterogeneity affect crack growth trajectory in human cortical bone. We used a phase field fracture framework on 2D models of cortical microstructure created from human tibias to analyze crack propagation. The increased AGEs level results in a higher rate of crack formation. The simulations also indicate that the mismatch between the fracture properties (e.g., critical energy release rate) of osteons and interstitial tissue can alter the post-yielding behavior. The results show that if the critical energy release rate of cement lines is lower than that of osteons and the surrounding interstitial matrix, cracks can be arrested by cement lines. Additionally, activation of toughening mechanisms such as crack merging and branching depends on bone microstructural morphology (i.e., osteons geometrical parameters, canals, and lacunae porosities). In conclusion, the present findings suggest that materials heterogeneity of microstructural features and the crack-microstructure interactions can play important roles in bone fragility.
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Details
- Title
- Fracture behavior of human cortical bone: Role of advanced glycation end-products and microstructural features
- Creators
- Ebrahim Maghami - Drexel UniversityTimothy O. Josephson - Drexel UniversityJason P. Moore - Drexel UniversityTaraneh Rezaee - University of Massachusetts DartmouthTheresa A. Freeman - Thomas Jefferson UniversityLamya Karim - University of Massachusetts DartmouthAhmad R. Najafi - Drexel University
- Publication Details
- Journal of biomechanics, v 125, 110600
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000685352000009
- Scopus ID
- 2-s2.0-85109428323
- Other Identifier
- 991019168655704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical