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Journal article
Fracture behavior of human cortical bone with high glycation content under dynamic loading
Journal of the mechanical behavior of biomedical materials, v 155, 106577
17 May 2024
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
The present study simulates the fracture behavior of diabetic cortical bone with high levels of advanced glycation end-products (AGEs) under dynamic loading. We consider that the increased AGEs in diabetic cortical bone degrade the materials heterogeneity of cortical bone through a reduction in critical energy release rates of the microstructural features. To simulate the initiation and propagation of cracks, we implement a phase field fracture framework on 2D models of human tibia cortical microstructure. The simulations show that the mismatch between the fracture properties (e.g., critical energy release rate) of osteons and interstitial tissue due to high AGEs contents can change crack growth trajectories. The results show crack branching in the cortical microstructure under dynamic loading is affected by the mismatches related to AGEs. In addition, we observe cortical features such as osteons and cement lines can prevent multiple cracking under dynamic loading even with changing the mismatches due to high AGEs. Furthermore, under dynamic loading, some toughening mechanisms can be activated and deactivated with different AGEs contents. In conclusion, the current findings present that the combination of the loading type and materials heterogeneity of microstructural features can change the fracture response of diabetic cortical bone and its fragility.
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Details
- Title
- Fracture behavior of human cortical bone with high glycation content under dynamic loading
- Creators
- Ahmad Raeisi Najafi (Corresponding Author) - Drexel University, Mechanical Engineering and MechanicsEbrahim Maghami - Drexel UniversityAmirreza Sadighi - Drexel University
- Publication Details
- Journal of the mechanical behavior of biomedical materials, v 155, 106577
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- NSF CAREER Award: CMMI-2143422
This study was supported by faculty start-up funding from the Department of Mechanical Engineering and Mechanics at Drexel University. The development of the dynamic fracture framework is also supported by the NSF CAREER Award CMMI-2143422.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:001295315500001
- Scopus ID
- 2-s2.0-85193054288
- Other Identifier
- 991021874715604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials