Journal article
Free-form fabrication and micro-CT characterization of poly-/spl epsiv/-caprolactone tissue scaffolds
IEEE engineering in medicine and biology magazine, v 24(1)
Jan 2005
PMID: 15709540
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
One of the dominant approaches to tissue engineering is the seeding of biodegradable, biocompatible polymer scaffolds with progenitor cells prior to three-dimensional (3-D) culture or implantation. While the macroarchitecture of these scaffolds is important for anatomic fit, the microarchitecture has direct effects upon the ability of cells to attach, migrate, and thrive. Free-form fabrication - specifically, fused deposition - allows for simultaneous control of scaffold shape and microarchitectural characteristics. Microtomographic (micro-CT) scanners enable high-speed 3-D characterization of the salient features of these polymer scaffolds. A micro-CT scan followed by a 3-D reconstruction of serial image sections can determine porosity, pore size, pore interconnectivity, strut size, and 3-D microarchitecture. In this study, a number of polymer samples with different microarchitectures were manufactured through fused deposition free-form fabrication and subsequently characterized through micro-CT analysis. A desktop micro-CT scanner was used to examine each sample at approximately 19.1 μm resolution. Three-dimensional reconstruction and an analysis of core regions of each sample were performed. The results indicate that scaffolds of a specific shape may be constructed with interconnected pores of desired size.
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Details
- Title
- Free-form fabrication and micro-CT characterization of poly-/spl epsiv/-caprolactone tissue scaffolds
- Creators
- A.L Darling - Drexel UniversityWei Sun - Drexel University
- Publication Details
- IEEE engineering in medicine and biology magazine, v 24(1)
- Publisher
- IEEE
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000226366400016
- Scopus ID
- 2-s2.0-13244284637
- Other Identifier
- 991019167580104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Medical Informatics