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Published, Version of Record (VoR)Open Access Discount via Drexel Libraries Read and Publish Program 2025CC BY V4.0, Open
Journal article
From Resuscitation to Rehabilitation: The Post-Intensive Care Syndrome Continuum in Sepsis Care
Journal of clinical medicine, v 14(23), 8374
26 Nov 2025
PMID: 41375677
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Sepsis and septic shock affect nearly 49 million people worldwide each year. Although advances in early recognition and evidence-based management have improved survival, many patients experience long-term cognitive, physical, and psychological impairments collectively known as post-intensive care syndrome (PICS). These sequelae often extend to families and caregivers (PICS-F), resulting in lasting declines in quality of life. Recovery from sepsis represents a continuum that begins during intensive care and extends into survivorship. Decisions regarding analgesia, sedation, delirium prevention, mobilization, and family engagement shape this recovery trajectory. The ABCDEF bundle provides an evidence-based framework to mitigate these long-term effects through structured approaches to pain control, paired awakening and breathing trials, targeted sedation, early mobility, and family involvement. This narrative review synthesizes current evidence on PICS in sepsis and septic shock and examines how implementation of the ABCDEF bundle across the continuum of care can reduce the incidence and severity of post-ICU impairments. Reframing sepsis survivorship as an ongoing process rather than an endpoint underscores the need for critical care practices that promote not only survival but also restoration of function, cognition, and quality of life.
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Details
- Title
- From Resuscitation to Rehabilitation: The Post-Intensive Care Syndrome Continuum in Sepsis Care
- Creators
- Matthew Sherman - Allegheny General HospitalPerry Y Lim (Corresponding Author) - Drexel University, General Internal MedicineTariq Cheema - Drexel University, General Internal MedicineBriana E Disilvio - Allegheny General HospitalPerry John Tiberio - Drexel University, General Internal Medicine
- Publication Details
- Journal of clinical medicine, v 14(23), 8374
- Publisher
- MDPI
- Number of pages
- 16
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001634930900001
- Scopus ID
- 2-s2.0-105024535650
- Other Identifier
- 991022135143704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Critical Care Medicine