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Front Cover: Asmic Isocyanide‐Nitrile Isomerization‐Alkylations (Eur. J. Org. Chem. 29/2019)
Journal article   Open access   Peer reviewed

Front Cover: Asmic Isocyanide‐Nitrile Isomerization‐Alkylations (Eur. J. Org. Chem. 29/2019)

Embarek Alwedi, J. Armando Lujan-Montelongo, Rodrigo Cortés-Mejía, Jorge M. del Campo, Bilal Altundas and Fraser F. Fleming
European journal of organic chemistry, v 2019(29), pp 4624-4624
07 Aug 2019
DOI: https://doi.org/10.1002/ejoc.201900999
url
https://doi.org/10.1002/ejoc.201900999View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

The Front Cover shows a representation of a synthetic application of the versatile building block Anisylsulfanylmethylisocyanide (Asmic). After Asmic is decorated through alkylations (the gymnast on the left), an isocyanide to nitrile isomerization is triggered by the use of nBuLi, expelling a transient carbene which receive a reoriented cyanide to afford a lithiated nitrile, whose alkylation leads to a quaternary nitrile  (the gymnast with a winning stance on the right). As the rearrangement occurs swiftly at unprecedented low temperatures, the audience is inevitably impressed! Cover design by Mariana Murillo and Dr. J. Armando Lujan‐Montelongo. More information can be found in the Full Paper by J. M. del Campo, F. F. Fleming et al.

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